Cyclin-dependent kinase 14

Function

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

Classification

Family (Pfam)

PF00069 Pkinase

InterPro

CDK, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS

Functional cluster

Serine/Threonine Protein Kinases

Gene Ontology · 16

• GO:0000307 cyclin-dependent protein kinase holoenzyme complex
• GO:0005737 cytoplasm
• GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex
• GO:0005829 cytosol
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0005886 plasma membrane
• GO:0005524 ATP binding
• GO:0030332 cyclin binding
• GO:0004693 cyclin-dependent protein serine/threonine kinase activity
• GO:0106310 protein serine kinase activity
• GO:0051301 cell division
• GO:0000086 G2/M transition of mitotic cell cycle
• GO:0060828 regulation of canonical Wnt signaling pathway
• GO:1901987 regulation of cell cycle phase transition
• GO:0016055 Wnt signaling pathway

Drugs targeting this protein · 4

• PHA-793887 inhibitor
• RONICICLIB inhibitor
• AT-7519 inhibitor
• AZD-5438 inhibitor

Related proteins · sequence + function similarity

• Cyclin-dependent kinase 14 1.00
• Cyclin-dependent kinase 14 1.00
• Cyclin-dependent kinase 14 0.98
• Cyclin-dependent kinase 14 0.98
• Cyclin-dependent kinase 14 0.98
• Cyclin-dependent kinase 14 0.98
• Cyclin-dependent kinase 14 0.98
• Cyclin-dependent kinase 17 0.89
• Cyclin-dependent kinase 18 0.88
• Cyclin-dependent kinase 18 0.88
• Cyclin-dependent kinase 18 0.88
• Cyclin-dependent kinase 18 0.88

Co-cited proteins · studied together in the literature

• Cyclin-Y 3 shared papers
• Septin-8 1 shared papers
• Low-density lipoprotein receptor-related protein 6 2 shared papers
• Caprin-2 1 shared papers

Literature · 18 cited papers

• Caprin-2 positively regulates CDK14/Cyclin Y-mediated LRP5/6 constitutive phosphorylation. J. Biol. Chem. · 2016
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Cell cycle control of wnt receptor activation. Dev. Cell · 2009
• Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. FEBS Lett. · 2009
• Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• Functional characterization of human PFTK1 as a cyclin-dependent kinase. Proc. Natl. Acad. Sci. U.S.A. · 2007
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins. Cell Res. · 2006
• An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport. Proc. Natl. Acad. Sci. U.S.A. · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• … and 6 more in the literature graph