Guanylate cyclase soluble subunit alpha-1
Also known as: GUC1A3, GUCSA3, GUCY1A1, GUCY1A3
Classification
- Family (Pfam)
- PF00211 Guanylate_cyc, PF07701 HNOBA
- InterPro
- A/G_cyclase, A/G_cyclase_CS, H-NOX_domain_sf, HNOB_dom_associated, HNOB_dom_associated_sf, NO_sig/Golgi_transp_ligand-bd, Nucleotide_cyclase
- Functional cluster
- Zinc-Finger & Chromatin Regulatory Proteins
Experimental structures · PDB · 12
- 3UVJ X-ray 2.08A
- 4NI2 X-ray 1.90A
- 6JT0 EM 4.00A
- 6JT1 EM 3.90A
- 6JT2 EM 3.80A
- 7D9R EM 3.30A
- 7D9S EM 3.40A
- 7D9T EM 4.10A
- 7D9U EM 3.80A
- 8HBE EM 3.20A
- 8HBF EM 3.10A
- 8HBH EM 3.10A
A predicted model is available from AlphaFold.
Gene Ontology · 15
- GO:0005829 cytosol
- GO:0098982 GABA-ergic synapse
- GO:0098978 glutamatergic synapse
- GO:0008074 guanylate cyclase complex, soluble
- GO:0005654 nucleoplasm
- GO:0005525 GTP binding
- GO:0004383 guanylate cyclase activity
- GO:0020037 heme binding
- GO:0038023 signaling receptor activity
- GO:0008015 blood circulation
- GO:0006182 cGMP biosynthetic process
- GO:0007263 nitric oxide mediated signal transduction
- GO:0038060 nitric oxide-cGMP-mediated signaling
- GO:0070482 response to oxygen levels
- GO:0098925 retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
Disease associations
- Moyamoya disease with early-onset achalasia MONDO:0014331
Drugs targeting this protein · 13
- NITRIC OXIDE activator
- CINACIGUAT activator
- ISOSORBIDE MONONITRATE activator
- ATACIGUAT activator
- RIOCIGUAT positive allosteric modulator
- METHYLENE BLUE ANHYDROUS inhibitor
- VERICIGUAT activator
- PRALICIGUAT activator
- OLINCIGUAT positive allosteric modulator
- RUNCACIGUAT activator
- PENTAERYTHRITOL TETRANITRATE activator
- ISOSORBIDE DINITRATE activator
- NITROGLYCERIN activator
Related proteins · sequence + function similarity
- Guanylate cyclase soluble subunit alpha-1 0.99
- Guanylate cyclase soluble subunit alpha-1 0.98
- Guanylate cyclase soluble subunit alpha-1 0.97
- Guanylate cyclase soluble subunit alpha-1 0.93
- Guanylate cyclase soluble subunit alpha-2 0.87
- Guanylate cyclase soluble subunit alpha-2 0.87
- Guanylate cyclase soluble subunit alpha-2 0.86
- Soluble guanylate cyclase gcy-37 0.79
- Soluble guanylate cyclase gcy-32 0.71
- Guanylate cyclase soluble subunit beta-2 0.71
- Guanylate cyclase soluble subunit beta-2 0.71
- Soluble guanylate cyclase gcy-34 0.69
Co-cited proteins · studied together in the literature
- Guanylate cyclase soluble subunit beta-1 3 shared papers
Literature · 8 cited papers
- Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity. Biochemistry · 2014
- Loss of alpha1beta1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia. Am. J. Hum. Genet. · 2014
- Crystal structures of the catalytic domain of human soluble guanylate cyclase. PLoS ONE · 2013
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Human soluble guanylate cyclase: functional expression and revised isoenzyme family. Biochem. J. · 1998
- Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. FEBS Lett. · 1992
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