Guanylate cyclase soluble subunit beta-1
Also known as: GUC1B3, GUCSB3, GUCY1B1, GUCY1B3
Function
Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
Classification
- Family (Pfam)
- PF00211 Guanylate_cyc, PF07700 HNOB, PF07701 HNOBA
- InterPro
- A/G_cyclase, A/G_cyclase_CS, H-NOX_domain_sf, Heme_NO-bd, HNOB_dom_associated, HNOB_dom_associated_sf, NO_sig/Golgi_transp_ligand-bd, Nucleotide_cyclase
- Functional cluster
- Mixed Regulatory & Membrane Proteins
Experimental structures · PDB · 14
- 2WZ1 X-ray 1.63A
- 3UVJ X-ray 2.08A
- 4NI2 X-ray 1.90A
- 5MNW NMR
- 6JT0 EM 4.00A
- 6JT1 EM 3.90A
- 6JT2 EM 3.80A
- 7D9R EM 3.30A
- 7D9S EM 3.40A
- 7D9T EM 4.10A
- 7D9U EM 3.80A
- 8HBE EM 3.20A
- … and 2 more
A predicted model is available from AlphaFold.
Gene Ontology · 20
- GO:0005829 cytosol
- GO:0098978 glutamatergic synapse
- GO:0008074 guanylate cyclase complex, soluble
- GO:0098831 presynaptic active zone cytoplasmic component
- GO:0004016 adenylate cyclase activity
- GO:0047805 cytidylate cyclase activity
- GO:0005525 GTP binding
- GO:0004383 guanylate cyclase activity
- GO:0020037 heme binding
- GO:0051879 Hsp90 protein binding
- GO:0046872 metal ion binding
- GO:0070026 nitric oxide binding
- GO:0044877 protein-containing complex binding
- GO:0038023 signaling receptor activity
- GO:0008015 blood circulation
- GO:0071732 cellular response to nitric oxide
- GO:0006182 cGMP biosynthetic process
- GO:0007263 nitric oxide mediated signal transduction
- GO:0038060 nitric oxide-cGMP-mediated signaling
- GO:0070482 response to oxygen levels
Drugs targeting this protein · 13
- NITRIC OXIDE activator
- CINACIGUAT activator
- ISOSORBIDE MONONITRATE activator
- ATACIGUAT activator
- RIOCIGUAT positive allosteric modulator
- METHYLENE BLUE ANHYDROUS inhibitor
- VERICIGUAT activator
- PRALICIGUAT activator
- OLINCIGUAT positive allosteric modulator
- RUNCACIGUAT activator
- PENTAERYTHRITOL TETRANITRATE activator
- ISOSORBIDE DINITRATE activator
- NITROGLYCERIN activator
Related proteins · sequence + function similarity
- Guanylate cyclase soluble subunit beta-1 1.00
- Guanylate cyclase soluble subunit beta-1 1.00
- Guanylate cyclase soluble subunit beta-1 1.00
- Guanylate cyclase soluble subunit beta-1 1.00
- GATOR1 complex protein NPRL2 0.67
- GATOR1 complex protein NPRL2 0.67
- GATOR1 complex protein NPRL2 0.67
- Translocation protein SEC63 homolog 0.66
- Translocation protein SEC63 homolog 0.66
- Translocation protein SEC63 homolog 0.66
- Cleavage and polyadenylation specificity factor subunit 3 0.65
- Cleavage and polyadenylation specificity factor subunit 3 0.65
Co-cited proteins · studied together in the literature
- Guanylate cyclase soluble subunit alpha-1 3 shared papers
Literature · 7 cited papers
- Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity. Biochemistry · 2014
- Crystal structures of the catalytic domain of human soluble guanylate cyclase. PLoS ONE · 2013
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Heterogeneity in human soluble guanylate cyclase due to alternative splicing. FEBS Lett. · 1991
- Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. FEBS Lett. · 1992
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