Guanylate cyclase soluble subunit beta-2

Classification

Family (Pfam)

PF00211 Guanylate_cyc, PF07700 HNOB, PF07701 HNOBA

InterPro

A/G_cyclase, A/G_cyclase_CS, H-NOX_domain_sf, Heme_NO-bd, HNOB_dom_associated, HNOB_dom_associated_sf, NO_sig/Golgi_transp_ligand-bd, Nucleotide_cyclase

Functional cluster

Serine/Threonine Protein Kinases

Gene Ontology · 8

• GO:0005829 cytosol
• GO:0008074 guanylate cyclase complex, soluble
• GO:0005525 GTP binding
• GO:0004383 guanylate cyclase activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding
• GO:0035556 intracellular signal transduction
• GO:0070482 response to oxygen levels

Drugs targeting this protein · 13

• NITRIC OXIDE activator
• CINACIGUAT activator
• ISOSORBIDE MONONITRATE activator
• ATACIGUAT activator
• RIOCIGUAT positive allosteric modulator
• METHYLENE BLUE ANHYDROUS inhibitor
• VERICIGUAT activator
• PRALICIGUAT activator
• OLINCIGUAT positive allosteric modulator
• RUNCACIGUAT activator
• PENTAERYTHRITOL TETRANITRATE activator
• ISOSORBIDE DINITRATE activator
• NITROGLYCERIN activator

Related proteins · sequence + function similarity

• Guanylate cyclase soluble subunit beta-2 0.94
• Soluble guanylate cyclase gcy-31 0.84
• Soluble guanylate cyclase gcy-37 0.83
• Soluble guanylate cyclase gcy-35 0.83
• Soluble guanylate cyclase gcy-34 0.81
• Soluble guanylate cyclase gcy-32 0.80
• Soluble guanylate cyclase 89Db 0.75
• Soluble guanylate cyclase 89Da 0.74
• Guanylate cyclase soluble subunit alpha-2 0.73
• Guanylate cyclase soluble subunit alpha-2 0.72
• Soluble guanylate cyclase gcy-36 0.72
• Guanylate cyclase soluble subunit alpha-2 0.72

Literature · 2 cited papers

• The beta(2) subunit of soluble guanylyl cyclase contains a human-specific frameshift and is expressed in gastric carcinoma. Biochem. Biophys. Res. Commun. · 2000
• Assignment of GUCY1B2, the gene coding for the beta2 subunit of human guanylyl cyclase to chromosomal band 13q14.3 between markers D13S168 and D13S155. Genomics · 1999