Guanylate cyclase soluble subunit alpha-2

UniProt P33402 Organism Homo sapiens Gene GUC1A2, GUCSA2, GUCY1A2 EC 4.6.1.2

Also known as: GUC1A2, GUCSA2, GUCY1A2

Function

Alpha subunit of soluble guanylate cyclase (sGC), a central enzyme in nitric oxide (NO) signaling. Functions as the main intracellular receptor for NO. Upon NO binding, catalyzes the conversion of GTP to cyclic GMP (cGMP) and thereby transducing NO signal into a ubiquitous intracellular second messenger.

Classification

Family (Pfam): PF00211 Guanylate_cyc, PF07700 HNOB, PF07701 HNOBA
InterPro: A/G_cyclase, A/G_cyclase_CS, H-NOX_domain_sf, Heme_NO-bd, HNOB_dom_associated, HNOB_dom_associated_sf, NO_sig/Golgi_transp_ligand-bd, Nucleotide_cyclase
Functional cluster: Zinc-Finger & Ubiquitination Proteins

Gene Ontology · 8

Drugs targeting this protein · 13

NITRIC OXIDE activator
CINACIGUAT activator
ISOSORBIDE MONONITRATE activator
ATACIGUAT activator
RIOCIGUAT positive allosteric modulator
METHYLENE BLUE ANHYDROUS inhibitor
VERICIGUAT activator
PRALICIGUAT activator
OLINCIGUAT positive allosteric modulator
RUNCACIGUAT activator
PENTAERYTHRITOL TETRANITRATE activator
ISOSORBIDE DINITRATE activator
NITROGLYCERIN activator

Related proteins · sequence + function similarity

Literature · 6 cited papers

The consensus coding sequences of human breast and colorectal cancers. Science · 2006
Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase. Biochem. J. · 1998
A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein. J. Biol. Chem. · 1995
Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme. FEBS Lett. · 1991

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