Ephrin type-B receptor 1

UniProt P54762 Organism Homo sapiens Gene ELK, EPHB1, EPHT2, HEK6, NET EC 2.7.10.1

Also known as: ELK, EPHB1, EPHT2, HEK6, NET

Function

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity).

Classification

Family (Pfam): PF14575 EphA2_TM, PF25599 Ephrin_CRD, PF01404 Ephrin_lbd, PF00041 fn3, PF07714 PK_Tyr_Ser-Thr, PF00536 SAM_1
InterPro: Eph_TM, EphB1_rcpt_lig-bd, EphB1_SAM, Ephrin_rcpt_lig-bd_dom, Ephrin_rcpt_TKs, FN3_dom, FN3_sf, Galactose-bd-like_sf, Growth_fac_rcpt_cys_sf, Ig-like_fold, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, SAM, SAM/pointed_sf, Ser-Thr/Tyr_kinase_cat_dom, Tyr_kinase_AS, Tyr_kinase_cat_dom, Tyr_kinase_ephrin_rcpt, Tyr_kinase_rcpt_V_CS
Functional cluster: Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 8

2DJS NMR
2EAO NMR
3ZFX X-ray 2.50A
5MJA X-ray 2.14A
5MJB X-ray 2.23A
6UMW X-ray 1.98A
7KPL X-ray 2.71A
7KPM X-ray 1.61A

A predicted model is available from AlphaFold.

Gene Ontology · 36

Drugs targeting this protein · 1

VANDETANIB inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Ephrin type-B receptor 6 1 shared papers
Ephrin type-B receptor 1 4 shared papers
Low molecular weight phosphotyrosine protein phosphatase 1 shared papers
Growth factor receptor-bound protein 7 1 shared papers
Growth factor receptor-bound protein 2 2 shared papers
SH2/SH3 adapter protein NCK1 1 shared papers
Ephrin type-A receptor 1 2 shared papers
E3 ubiquitin-protein ligase CBL 1 shared papers
Ephrin type-A receptor 7 1 shared papers
Ephrin type-B receptor 3 1 shared papers
Ephrin type-B receptor 4 2 shared papers
Ephrin type-A receptor 5 1 shared papers

Literature · 15 cited papers

Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. Arthritis Res. Ther. · 2008
Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway. Traffic · 2008
Patterns of somatic mutation in human cancer genomes. Nature · 2007
The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J. Cell Biol. · 2003
EphB1 associates with Grb7 and regulates cell migration. J. Biol. Chem. · 2002
The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. J. Biol. Chem. · 2002
Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. Genes Dev. · 1998
Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase. J. Biol. Chem. · 1998
… and 3 more in the literature graph

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