Ephrin type-A receptor 7

Function

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7.

Classification

Family (Pfam)

PF14575 EphA2_TM, PF25599 Ephrin_CRD, PF01404 Ephrin_lbd, PF07699 Ephrin_rec_like, PF00041 fn3, PF07714 PK_Tyr_Ser-Thr, PF00536 SAM_1

InterPro

Eph_TM, EphA7_rcpt_lig-bd, Ephrin_rcpt_lig-bd_dom, Ephrin_rcpt_TKs, FN3_dom, FN3_sf, Galactose-bd-like_sf, Growth_fac_rcpt_cys_sf, Ig-like_fold, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, SAM, SAM/pointed_sf, Ser-Thr/Tyr_kinase_cat_dom, Tyr-kin_ephrin_A/B_rcpt-like, Tyr_kinase_AS, Tyr_kinase_cat_dom, Tyr_kinase_ephrin_rcpt, Tyr_kinase_rcpt_V_CS

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 7

• 2REI X-ray 1.60A
• 3DKO X-ray 2.00A
• 3H8M X-ray 2.10A
• 3NRU X-ray 2.30A
• 7EEC X-ray 3.10A
• 7EED X-ray 3.05A
• 7EEF X-ray 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 33

• GO:0030425 dendrite
• GO:0098978 glutamatergic synapse
• GO:0098686 hippocampal mossy fiber to CA3 synapse
• GO:0031594 neuromuscular junction
• GO:0043025 neuronal cell body
• GO:0005886 plasma membrane
• GO:0098839 postsynaptic density membrane
• GO:0098685 Schaffer collateral - CA1 synapse
• GO:0005524 ATP binding
• GO:0008046 axon guidance receptor activity
• GO:0045499 chemorepellent activity
• GO:0046875 ephrin receptor binding
• GO:0005004 GPI-linked ephrin receptor activity
• GO:0019838 growth factor binding
• GO:0004713 protein tyrosine kinase activity
• GO:0005005 transmembrane-ephrin receptor activity
• GO:0006915 apoptotic process
• GO:0007411 axon guidance
• GO:0007420 brain development
• GO:0048755 branching morphogenesis of a nerve
• GO:0048013 ephrin receptor signaling pathway
• GO:0050804 modulation of chemical synaptic transmission
• GO:0050919 negative chemotaxis
• GO:0048671 negative regulation of collateral sprouting
• GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• GO:0051964 negative regulation of synapse assembly
• GO:0016310 phosphorylation
• GO:0043525 positive regulation of neuron apoptotic process
• GO:0022407 regulation of cell-cell adhesion
• GO:0070372 regulation of ERK1 and ERK2 cascade
• GO:0050730 regulation of peptidyl-tyrosine phosphorylation
• GO:0099175 regulation of postsynapse organization
• GO:0031952 regulation of protein autophosphorylation

Drugs targeting this protein · 1

• VANDETANIB inhibitor

Related proteins · sequence + function similarity

• Ephrin type-A receptor 7 1.00
• Ephrin type-A receptor 7 1.00
• Ephrin type-A receptor 7 1.00
• Ephrin type-A receptor 4 0.96
• Ephrin type-A receptor 4-B 0.96
• Ephrin type-A receptor 4-A 0.95
• Ephrin type-B receptor 2 0.95
• Ephrin type-A receptor 5 0.95
• Ephrin type-A receptor 5 0.95
• Ephrin type-B receptor 2 0.95
• Ephrin type-A receptor 4 0.95
• Ephrin type-B receptor 2 0.95

Co-cited proteins · studied together in the literature

• Ephrin type-A receptor 5 2 shared papers
• Ephrin type-A receptor 4 2 shared papers
• Ephrin type-B receptor 2 2 shared papers
• Ephrin type-B receptor 3 1 shared papers
• Ephrin type-A receptor 1 1 shared papers
• Ephrin type-A receptor 3 1 shared papers
• Ephrin type-A receptor 8 1 shared papers
• Ephrin type-B receptor 1 1 shared papers
• Ephrin type-B receptor 4 1 shared papers
• Ephrin type-A receptor 2 1 shared papers

Literature · 9 cited papers

• Secreted form of EphA7 in lung cancer. Int. J. Oncol. · 2010
• ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias. Proc. Natl. Acad. Sci. U.S.A. · 2007
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The consensus coding sequences of human breast and colorectal cancers. Science · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The DNA sequence and analysis of human chromosome 6. Nature · 2003
• Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell · 1997
• cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. Oncogene · 1995