Ephrin type-B receptor 6

Function

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Can recruit SH2 domain-containing signaling adapters following phosphorylation by EPHB4.

Classification

Family (Pfam)

PF14575 EphA2_TM, PF25599 Ephrin_CRD, PF01404 Ephrin_lbd, PF07699 Ephrin_rec_like, PF00041 fn3, PF07714 PK_Tyr_Ser-Thr, PF07647 SAM_2

InterPro

Eph_TM, Ephrin_rcpt_lig-bd_dom, Ephrin_rcpt_TKs, FN3_dom, FN3_sf, Galactose-bd-like_sf, Growth_fac_rcpt_cys_sf, Ig-like_fold, Kinase-like_dom_sf, Prot_kinase_dom, SAM, SAM/pointed_sf, Ser-Thr/Tyr_kinase_cat_dom, Tyr-kin_ephrin_A/B_rcpt-like, Tyr_kinase_ephrin_rcpt, Tyr_kinase_rcpt_V_CS

Functional cluster

Secreted Growth Factors & Cytokines

Experimental structures · PDB · 1

• 7K7J X-ray 3.00A

A predicted model is available from AlphaFold.

Gene Ontology · 10

• GO:0005829 cytosol
• GO:0030425 dendrite
• GO:0005576 extracellular region
• GO:0005886 plasma membrane
• GO:0005524 ATP binding
• GO:0005003 ephrin receptor activity
• GO:0038023 signaling receptor activity
• GO:0005005 transmembrane-ephrin receptor activity
• GO:0007411 axon guidance
• GO:0048013 ephrin receptor signaling pathway

Drugs targeting this protein · 1

• VANDETANIB inhibitor

Related proteins · sequence + function similarity

• Ephrin type-B receptor 6 1.00
• Ephrin type-B receptor 6 0.99
• Ephrin type-B receptor 6 0.99
• Ephrin type-A receptor 10 0.96
• Ephrin type-A receptor 10 0.95
• Ephrin type-A receptor 1 0.92
• Ephrin type-A receptor 1 0.90
• Ephrin type-B receptor 4 0.90
• Ephrin type-B receptor 4 0.87
• Tyrosine-protein kinase receptor TYRO3 0.84
• Ephrin type-A receptor 8 0.84
• Tyrosine-protein kinase receptor Tie-1 0.83

Co-cited proteins · studied together in the literature

• Ephrin type-A receptor 10 1 shared papers
• Ephrin type-B receptor 1 1 shared papers
• Ephrin type-B receptor 4 1 shared papers

Literature · 14 cited papers

• The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs. Biochem. J. · 2021
• EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells. Oncogene · 2009
• Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients. Cancer Sci. · 2008
• Identification of EphB6 variant-derived epitope peptides recognized by cytotoxic T-lymphocytes from HLA-A24+ malignant glioma patients. Oncol. Rep. · 2008
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The consensus coding sequences of human breast and colorectal cancers. Science · 2006
• Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. J. Biol. Chem. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. · 2004
• The DNA sequence of human chromosome 7. Nature · 2003
• Human chromosome 7: DNA sequence and biology. Science · 2003
• The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses. J. Biol. Chem. · 2003
• … and 2 more in the literature graph