Ephrin type-A receptor 10

Function

Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.

Classification

Family (Pfam)

PF14575 EphA2_TM, PF25599 Ephrin_CRD, PF01404 Ephrin_lbd, PF00041 fn3, PF07714 PK_Tyr_Ser-Thr, PF07647 SAM_2

InterPro

Eph_TM, Ephrin_rcpt_lig-bd_dom, Ephrin_rcpt_TKs, FN3_dom, FN3_sf, Galactose-bd-like_sf, Ig-like_fold, Kinase-like_dom_sf, Prot_kinase_dom, SAM, SAM/pointed_sf, Ser-Thr/Tyr_kinase_cat_dom, Tyr_kinase_ephrin_rcpt, Tyr_kinase_rcpt_V_CS

Functional cluster

Secreted Growth Factors & Cytokines

Gene Ontology · 8

• GO:0030425 dendrite
• GO:0005576 extracellular region
• GO:0016020 membrane
• GO:0005886 plasma membrane
• GO:0005524 ATP binding
• GO:0005005 transmembrane-ephrin receptor activity
• GO:0007411 axon guidance
• GO:0048013 ephrin receptor signaling pathway

Disease associations

• hearing loss, autosomal dominant 88 MONDO:0859527

Drugs targeting this protein · 1

• VANDETANIB inhibitor

Related proteins · sequence + function similarity

• Ephrin type-A receptor 10 1.00
• Ephrin type-B receptor 6 0.96
• Ephrin type-B receptor 6 0.96
• Ephrin type-B receptor 6 0.96
• Ephrin type-B receptor 6 0.95
• Ephrin type-B receptor 4 0.89
• Ephrin type-A receptor 1 0.88
• Ephrin type-A receptor 8 0.86
• Ephrin type-B receptor 4 0.86
• Ephrin type-A receptor 1 0.85
• Ephrin type-A receptor 8 0.85
• Netrin-3 0.84

Co-cited proteins · studied together in the literature

• Ephrin type-A receptor 10 1 shared papers
• Ephrin type-B receptor 6 1 shared papers
• Ephrin type-B receptor 4 1 shared papers

Literature · 6 cited papers

• A non-coding variant in 5' untranslated region drove up-regulation of pseudo-kinase EPHA10 and caused non-syndromic hearing loss in humans. Hum. Mol. Genet. · 2023
• The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs. Biochem. J. · 2021
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis. Biochim. Biophys. Acta · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004