lmmol · Proteins

Potassium-transporting ATPase subunit beta

UniProt P51164 Organism Homo sapiens Gene ATP4B

Also known as: ATP4B

Function

The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity).

Classification

Family (Pfam)
PF00287 Na_K-ATPase
InterPro
Na/K_ATPase_sub_beta, Na/K_ATPase_sub_beta_sf
Functional cluster
Immunoglobulin-Domain Cell Adhesion Proteins

Gene Ontology · 13

Drugs targeting this protein · 13

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 5 cited papers

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