Sodium/potassium-transporting ATPase subunit beta-1

UniProt P05026 Organism Homo sapiens Gene ATP1B, ATP1B1

Also known as: ATP1B, ATP1B1

Function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1.

Classification

Family (Pfam): PF00287 Na_K-ATPase
InterPro: Na/K_ATPase_sub_beta, Na/K_ATPase_sub_beta_sf
Functional cluster: Nucleotide & Amino-Acid Biosynthesis Enzymes

Experimental structures · PDB · 9

7E1Z EM 3.20A
7E20 EM 2.70A
7E21 EM 2.90A
8D3U EM 3.70A
8D3V EM 3.40A
8D3W EM 3.50A
8D3X EM 4.10A
8D3Y EM 3.90A
8ZYJ EM 2.37A

A predicted model is available from AlphaFold.

Gene Ontology · 47

Drugs targeting this protein · 6

DESLANOSIDE inhibitor
DIGOXIN inhibitor
ISTAROXIME inhibitor
DIGITOXIN inhibitor
ACETYLDIGITOXIN inhibitor
LANATOSIDE C inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

E3 ubiquitin-protein ligase RNF183 1 shared papers
Potassium-transporting ATPase subunit beta 1 shared papers
Sodium/potassium-transporting ATPase subunit alpha-1 1 shared papers
Sodium/potassium-transporting ATPase subunit beta-2 1 shared papers
Membrane protein MLC1 1 shared papers
TNF receptor-associated factor 3 1 shared papers
Hepatic and glial cell adhesion molecule 1 shared papers
Aquaporin-4 1 shared papers
Unconventional myosin-XVI 1 shared papers
Kin of IRRE-like protein 3 1 shared papers
Transient receptor potential cation channel subfamily V member 4 1 shared papers
Serine hydroxymethyltransferase, mitochondrial 1 shared papers

Literature · 16 cited papers

Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6. J. Immunol. · 2021
Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its beta1 subunit. Biochem. Biophys. Res. Commun. · 2020
Autism and intellectual disability-associated KIRREL3 interacts with neuronal proteins MAP1B and MYO16 with potential roles in neurodevelopment. PLoS ONE · 2015
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations. Hum. Mol. Genet. · 2012
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. Biochemistry · 2009
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Nat. Biotechnol. · 2009
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J. Proteome Res. · 2009
The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Nat. Biotechnol. · 2003
… and 4 more in the literature graph

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.