Sodium/potassium-transporting ATPase subunit beta-2
Also known as: ATP1B2
Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Classification
- Family (Pfam)
- PF00287 Na_K-ATPase
- InterPro
- Na/K_ATPase_sub_beta, Na/K_ATPase_sub_beta_sf
- Functional cluster
- Nucleotide & Amino-Acid Biosynthesis Enzymes
Gene Ontology · 38
- GO:0016324 apical plasma membrane
- GO:0097450 astrocyte end-foot
- GO:0097449 astrocyte projection
- GO:0044298 cell body membrane
- GO:0071944 cell periphery
- GO:0031253 cell projection membrane
- GO:0005737 cytoplasm
- GO:0009897 external side of plasma membrane
- GO:0016328 lateral plasma membrane
- GO:0016020 membrane
- GO:0098984 neuron to neuron synapse
- GO:0001917 photoreceptor inner segment
- GO:0005886 plasma membrane
- GO:0005890 sodium:potassium-exchanging ATPase complex
- GO:0001671 ATPase activator activity
- GO:0051117 ATPase binding
- GO:0030674 protein-macromolecule adaptor activity
- GO:0141109 transporter activator activity
- GO:0086064 cell communication by electrical coupling involved in cardiac conduction
- GO:0031589 cell-substrate adhesion
- GO:0030007 intracellular potassium ion homeostasis
- GO:0006883 intracellular sodium ion homeostasis
- GO:0021670 lateral ventricle development
- GO:0086009 membrane repolarization
- GO:0061744 motor behavior
- GO:1903976 negative regulation of glial cell migration
- GO:0021944 neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration
- GO:0045494 photoreceptor cell maintenance
- GO:0120036 plasma membrane bounded cell projection organization
- GO:0010976 positive regulation of neuron projection development
- GO:1903288 positive regulation of potassium ion import across plasma membrane
- GO:1903278 positive regulation of sodium ion export across plasma membrane
- GO:1990573 potassium ion import across plasma membrane
- GO:0050821 protein stabilization
- GO:0001895 retina homeostasis
- GO:0036376 sodium ion export across plasma membrane
- GO:0021678 third ventricle development
- GO:0150104 transport across blood-brain barrier
Drugs targeting this protein · 6
- DESLANOSIDE inhibitor
- DIGOXIN inhibitor
- ISTAROXIME inhibitor
- DIGITOXIN inhibitor
- ACETYLDIGITOXIN inhibitor
- LANATOSIDE C inhibitor
Related proteins · sequence + function similarity
- Sodium/potassium-transporting ATPase subunit beta-2 1.00
- Sodium/potassium-transporting ATPase subunit beta-2 1.00
- Sodium/potassium-transporting ATPase subunit beta-2 1.00
- Sodium/potassium-transporting ATPase subunit beta-2 1.00
- Sodium/potassium-transporting ATPase subunit beta-2 1.00
- Sodium/potassium-transporting ATPase subunit beta-1 0.91
- Protein ATP1B4 0.90
- Sodium/potassium-transporting ATPase subunit beta-1 0.90
- Sodium/potassium-transporting ATPase subunit beta-1 0.89
- Sodium/potassium-transporting ATPase subunit beta-1 0.89
- Sodium/potassium-transporting ATPase subunit beta-1 0.89
- Sodium/potassium-transporting ATPase subunit beta-1 0.89
Co-cited proteins · studied together in the literature
- Sodium/potassium-transporting ATPase subunit beta-2 2 shared papers
- Sodium/potassium-transporting ATPase subunit beta-2 1 shared papers
- Potassium-transporting ATPase subunit beta 1 shared papers
- Sodium/potassium-transporting ATPase subunit beta-1 1 shared papers
Literature · 8 cited papers
- A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. Biochemistry · 2009
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J. Proteome Res. · 2009
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Structure and expression of the human Na,K-ATPase beta 2-subunit gene. Gene · 1998
- Expression and synthesis of the Na,K-ATPase beta 2 subunit in human retinal pigment epithelium. Gene · 1996
- Nucleotide sequence of a cDNA for the beta 2 subunit isoform of Na+,K(+)-ATPase from human retina. Biochim. Biophys. Acta · 1994
- Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression. J. Biol. Chem. · 1989
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