lmmol · Proteins

Sodium/potassium-transporting ATPase subunit alpha-1

UniProt P05023 Organism Homo sapiens Gene ATP1A1 EC 7.2.2.13

Also known as: ATP1A1

Function

Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane. This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity).

Classification

Family (Pfam)
PF13246 Cation_ATPase, PF00689 Cation_ATPase_C, PF00690 Cation_ATPase_N, PF00122 E1-E2_ATPase
InterPro
ATPase_P-typ_cation-transptr_C, ATPase_P-typ_cation-transptr_N, ATPase_P-typ_cyto_dom_N, ATPase_P-typ_P_site, ATPase_P-typ_TM_dom_sf, ATPase_P-typ_transduc_dom_A_sf, ATPase_P-type_domA, Cation_transp_ATPase_P-type, HAD-like_sf, HAD_sf, P-type_ATPase_IIC, P_typ_ATPase, P_typ_ATPase_HD_dom
Functional cluster
Oxidoreductases, Catalases & Peroxidases

Experimental structures · PDB · 10

A predicted model is available from AlphaFold.

Gene Ontology · 46

Disease associations

Drugs targeting this protein · 6

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 25 cited papers

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