lmmol · Proteins

Potassium-transporting ATPase alpha chain 1

UniProt P20648 Organism Homo sapiens Gene ATP4A EC 7.2.2.19

Also known as: ATP4A

Function

The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity).

Classification

Family (Pfam)
PF13246 Cation_ATPase, PF00689 Cation_ATPase_C, PF00690 Cation_ATPase_N, PF00122 E1-E2_ATPase, PF09040 H-K_ATPase_N, PF08282 Hydrolase_3
InterPro
ATPase_P-typ_cation-transptr_C, ATPase_P-typ_cation-transptr_N, ATPase_P-typ_cyto_dom_N, ATPase_P-typ_H/K-transp_N, ATPase_P-typ_P_site, ATPase_P-typ_TM_dom_sf, ATPase_P-typ_transduc_dom_A_sf, ATPase_P-type_domA, Cation_transp_ATPase_P-type, HAD-like_sf, HAD_sf, P-type_ATPase_IIC, P_typ_ATPase, P_typ_ATPase_HD_dom
Functional cluster
Translational GTPases (EF-Tu/EF-G)

Gene Ontology · 15

Drugs targeting this protein · 13

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 5 cited papers

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