Sodium/potassium-transporting ATPase subunit beta-3

Function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

Classification

Family (Pfam)

PF00287 Na_K-ATPase

InterPro

Na/K_ATPase_sub_beta, Na/K_ATPase_sub_beta_sf

Functional cluster

Venom Serine Proteases & Phospholipase A2

Experimental structures · PDB · 7

• 9KCG EM 3.10A
• 9KCI EM 2.90A
• 9KCJ EM 3.10A
• 9KCK EM 2.90A
• 9KCL EM 2.90A
• 9KCM EM 2.90A
• 9KCR EM 3.20A

A predicted model is available from AlphaFold.

Gene Ontology · 22

• GO:0016324 apical plasma membrane
• GO:0016323 basolateral plasma membrane
• GO:0070062 extracellular exosome
• GO:0042470 melanosome
• GO:0005886 plasma membrane
• GO:0005890 sodium:potassium-exchanging ATPase complex
• GO:0036126 sperm flagellum
• GO:0001671 ATPase activator activity
• GO:0051117 ATPase binding
• GO:0030674 protein-macromolecule adaptor activity
• GO:0141109 transporter activator activity
• GO:0030007 intracellular potassium ion homeostasis
• GO:0006883 intracellular sodium ion homeostasis
• GO:0086009 membrane repolarization
• GO:1903288 positive regulation of potassium ion import across plasma membrane
• GO:1903278 positive regulation of sodium ion export across plasma membrane
• GO:1990573 potassium ion import across plasma membrane
• GO:0071805 potassium ion transmembrane transport
• GO:0072659 protein localization to plasma membrane
• GO:0050821 protein stabilization
• GO:0036376 sodium ion export across plasma membrane
• GO:0035725 sodium ion transmembrane transport

Drugs targeting this protein · 6

• DESLANOSIDE inhibitor
• DIGOXIN inhibitor
• ISTAROXIME inhibitor
• DIGITOXIN inhibitor
• ACETYLDIGITOXIN inhibitor
• LANATOSIDE C inhibitor

Related proteins · sequence + function similarity

• Sodium/potassium-transporting ATPase subunit beta-3 0.97
• Sodium/potassium-transporting ATPase subunit beta-3 0.97
• Sodium/potassium-transporting ATPase subunit beta-3 0.97
• Sodium/potassium-transporting ATPase subunit beta-3 0.96
• Sodium/potassium-transporting ATPase subunit beta-3 0.96
• Sodium/potassium-transporting ATPase subunit beta-3 0.95
• Sodium/potassium-transporting ATPase subunit beta-3 0.91
• Sodium/potassium-transporting ATPase subunit beta-1 0.90
• Sodium/potassium-transporting ATPase subunit beta-2 0.89
• Sodium/potassium-transporting ATPase subunit beta-1 0.89
• Protein ATP1B4 0.89
• Sodium/potassium-transporting ATPase subunit beta-3 0.88

Literature · 9 cited papers

• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J. Proteome Res. · 2006
• The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Nat. Biotechnol. · 2003
• Structural organization and chromosomal localization of the human Na,K- ATPase beta 3 subunit gene and pseudogene. Mamm. Genome · 1998
• Identification of the mammalian Na,K-ATPase 3 subunit. J. Biol. Chem. · 1996