Retinoic acid receptor RXR-gamma
Also known as: NR2B3, RXRG
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
Classification
- Family (Pfam)
- PF00104 Hormone_recep, PF11825 Nuc_recep-AF1, PF00105 zf-C4
- InterPro
- NHR-like_dom_sf, Nuc_recep-AF1, Nucl_hrmn_rcpt_lig-bd, Nuclear_hormone_rcpt_NR2, Nuclear_hrmn_rcpt, Retinoid-X_rcpt/HNF4, Znf_hrmn_rcpt, Znf_NHR/GATA
- Functional cluster
- Homeobox & Zinc-Finger Transcription Factors
Experimental structures · PDB · 2
A predicted model is available from AlphaFold.
Gene Ontology · 16
- GO:0000785 chromatin
- GO:0005737 cytoplasm
- GO:0005654 nucleoplasm
- GO:0090575 RNA polymerase II transcription regulator complex
- GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0140693 molecular condensate scaffold activity
- GO:0004879 nuclear receptor activity
- GO:0003707 nuclear steroid receptor activity
- GO:0044323 retinoic acid-responsive element binding
- GO:1990837 sequence-specific double-stranded DNA binding
- GO:0008270 zinc ion binding
- GO:0030154 cell differentiation
- GO:0006351 DNA-templated transcription
- GO:0007399 nervous system development
- GO:0045944 positive regulation of transcription by RNA polymerase II
- GO:0048384 retinoic acid receptor signaling pathway
Drugs targeting this protein · 6
- BEXAROTENE agonist
- ACITRETIN agonist
- MOFAROTENE modulator
- ETRETINATE agonist
- ALITRETINOIN agonist
- IRX-4204 agonist
Related proteins · sequence + function similarity
- Retinoic acid receptor RXR-gamma 1.00
- Retinoic acid receptor RXR-gamma 1.00
- Retinoic acid receptor RXR-gamma 1.00
- Retinoic acid receptor RXR-gamma 1.00
- Retinoic acid receptor RXR-gamma 0.99
- Retinoic acid receptor RXR-gamma 0.98
- Retinoic acid receptor RXR-alpha 0.97
- Retinoic acid receptor RXR-alpha-A 0.97
- Retinoic acid receptor RXR-alpha 0.97
- Retinoic acid receptor RXR-alpha 0.96
- Retinoic acid receptor RXR-alpha 0.96
- Retinoic acid receptor RXR-gamma 0.96
Co-cited proteins · studied together in the literature
- Nuclear receptor subfamily 4immunitygroup A member 1 1 shared papers
- Retinoic acid receptor RXR-alpha 2 shared papers
- Retinoic acid receptor RXR-alpha 1 shared papers
- Vascular cell adhesion protein 1 1 shared papers
- Retinoic acid receptor gamma 1 shared papers
- Retinoic acid receptor RXR-beta 1 shared papers
- Transcription factor GATA-6 1 shared papers
- Retinoic acid receptor beta 1 shared papers
- Krueppel-like factor 2 1 shared papers
- Histone acetyltransferase p300 1 shared papers
- Histone deacetylase 7 1 shared papers
- Peroxisome proliferator-activated receptor alpha 1 shared papers
Literature · 4 cited papers
- MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases. Proc. Natl. Acad. Sci. U.S.A. · 2017
- Orphan receptor TR3 attenuates the p300-induced acetylation of retinoid X receptor-alpha. Mol. Endocrinol. · 2007
- The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
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