Retinoic acid receptor beta

UniProt P10826 Organism Homo sapiens Gene HAP, NR1B2, RARB

Also known as: HAP, NR1B2, RARB

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Classification

Family (Pfam): PF00104 Hormone_recep, PF00105 zf-C4
InterPro: NHR-like_dom_sf, NR_DBD_RAR, NR_LBD_RAR, Nucl_hrmn_rcpt_lig-bd, Nuclear_hrmn_rcpt, Retinoic_acid_rcpt, Znf_hrmn_rcpt, Znf_NHR/GATA
Functional cluster: Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 9

1HRA NMR
1XAP X-ray 2.10A
4DM6 X-ray 1.90A
4DM8 X-ray 2.30A
4JYG X-ray 2.35A
4JYH X-ray 2.60A
4JYI X-ray 1.90A
5UAN X-ray 3.51A
6SSQ X-ray 2.30A

A predicted model is available from AlphaFold.

Gene Ontology · 18

Disease associations

microphthalmia, syndromic 12 MONDO:0014229

Drugs targeting this protein · 9

ACITRETIN agonist
ADAPALENE agonist
MOFAROTENE modulator
TAZAROTENE agonist
TAMIBAROTENE agonist
TRETINOIN agonist
ETRETINATE agonist
ISOTRETINOIN agonist
ALITRETINOIN agonist

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Retinoic acid receptor beta 1 shared papers
Nuclear receptor corepressor 2 1 shared papers
Retinoic acid receptor RXR-alpha 2 shared papers
Retinoic acid receptor RXR-alpha 1 shared papers
Vascular cell adhesion protein 1 1 shared papers
Retinoic acid receptor gamma 1 shared papers
Retinoic acid receptor RXR-gamma 1 shared papers
Retinoic acid receptor RXR-beta 1 shared papers
Transcription factor GATA-6 1 shared papers
Krueppel-like factor 2 1 shared papers
Histone deacetylase 7 1 shared papers
Peroxisome proliferator-activated receptor alpha 1 shared papers

Literature · 18 cited papers

The quaternary architecture of RARbeta-RXRalpha heterodimer facilitates domain-domain signal transmission. Nat. Commun. · 2017
MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases. Proc. Natl. Acad. Sci. U.S.A. · 2017
Gain-of-function mutations in RARB cause intellectual disability with progressive motor impairment. Hum. Mutat. · 2016
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Recessive and dominant mutations in retinoic acid receptor beta in cases with microphthalmia and diaphragmatic hernia. Am. J. Hum. Genet. · 2013
The consensus coding sequences of human breast and colorectal cancers. Science · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. Mol. Endocrinol. · 2003
Elevated retinoic acid receptor beta(4) protein in human breast tumor cells with nuclear and cytoplasmic localization. Proc. Natl. Acad. Sci. U.S.A. · 1999
The solution structure of the human retinoic acid receptor-beta DNA-binding domain. J. Biomol. NMR · 1993
Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines. Cancer Res. · 1994
Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Nature · 1986
… and 6 more in the literature graph

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