Retinoic acid receptor gamma

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Classification

Family (Pfam)

PF00104 Hormone_recep, PF00105 zf-C4

InterPro

NHR-like_dom_sf, NR_DBD_RAR, NR_LBD_RAR, Nucl_hrmn_rcpt_lig-bd, Nuclear_hrmn_rcpt, Retinoic_acid_rcpt, Znf_hrmn_rcpt, Znf_NHR/GATA

Functional cluster

RNA Polymerase II Transcription Factors

Experimental structures · PDB · 11

• 1EXA X-ray 1.59A
• 1EXX X-ray 1.67A
• 1FCX X-ray 1.47A
• 1FCY X-ray 1.30A
• 1FCZ X-ray 1.38A
• 1FD0 X-ray 1.38A
• 2LBD X-ray 2.06A
• 3LBD X-ray 2.40A
• 4LBD X-ray 2.50A
• 5M24 X-ray 1.69A
• 6FX0 X-ray 1.90A

A predicted model is available from AlphaFold.

Gene Ontology · 30

• GO:0000785 chromatin
• GO:0005737 cytoplasm
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0090575 RNA polymerase II transcription regulator complex
• GO:0005667 transcription regulator complex
• GO:0003682 chromatin binding
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0004879 nuclear receptor activity
• GO:0046965 nuclear retinoid X receptor binding
• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:1990837 sequence-specific double-stranded DNA binding
• GO:0008270 zinc ion binding
• GO:0060070 canonical Wnt signaling pathway
• GO:0030154 cell differentiation
• GO:0006351 DNA-templated transcription
• GO:0048048 embryonic eye morphogenesis
• GO:0035116 embryonic hindlimb morphogenesis
• GO:0003430 growth plate cartilage chondrocyte growth
• GO:0008285 negative regulation of cell population proliferation
• GO:0000122 negative regulation of transcription by RNA polymerase II
• GO:0043065 positive regulation of apoptotic process
• GO:0043068 positive regulation of programmed cell death
• GO:0045944 positive regulation of transcription by RNA polymerase II
• GO:0008361 regulation of cell size
• GO:0032526 response to retinoic acid
• GO:0048384 retinoic acid receptor signaling pathway

Drugs targeting this protein · 10

• ACITRETIN agonist
• ADAPALENE agonist
• MOFAROTENE modulator
• TAZAROTENE agonist
• PALOVAROTENE agonist
• TRIFAROTENE agonist
• TRETINOIN agonist
• ETRETINATE agonist
• ISOTRETINOIN agonist
• ALITRETINOIN agonist

Related proteins · sequence + function similarity

• Retinoic acid receptor gamma 0.99
• Retinoic acid receptor alpha 0.93
• Retinoic acid receptor alpha 0.93
• Retinoic acid receptor gamma 0.93
• Retinoic acid receptor alpha 0.93
• Retinoic acid receptor alpha 0.92
• Retinoic acid receptor gamma-A 0.92
• Retinoic acid receptor alpha-B 0.91
• Retinoic acid receptor alpha 0.90
• Retinoic acid receptor gamma 0.89
• Retinoic acid receptor alpha 0.89
• Retinoic acid receptor alpha 0.89

Co-cited proteins · studied together in the literature

• Retinoic acid receptor gamma 1 shared papers
• Retinoic acid receptor RXR-alpha 1 shared papers
• Vascular cell adhesion protein 1 1 shared papers
• Retinoic acid receptor RXR-gamma 1 shared papers
• Retinoic acid receptor RXR-beta 1 shared papers
• Transcription factor GATA-6 1 shared papers
• Retinoic acid receptor beta 1 shared papers
• Krueppel-like factor 2 1 shared papers
• Histone deacetylase 7 1 shared papers
• Peroxisome proliferator-activated receptor alpha 1 shared papers
• Histone deacetylase 5 1 shared papers
• Retinoic acid receptor alpha 1 shared papers

Literature · 13 cited papers

• MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases. Proc. Natl. Acad. Sci. U.S.A. · 2017
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• The consensus coding sequences of human breast and colorectal cancers. Science · 2006
• The finished DNA sequence of human chromosome 12. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Conformational adaptation of agonists to the human nuclear receptor RAR gamma. Nat. Struct. Biol. · 1998
• Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. Nature · 1995
• A third human retinoic acid receptor, hRAR-gamma. Proc. Natl. Acad. Sci. U.S.A. · 1989
• A functional retinoic acid receptor encoded by the gene on human chromosome 12. Mol. Endocrinol. · 1990
• Murine isoforms of retinoic acid receptor gamma with specific patterns of expression. Proc. Natl. Acad. Sci. U.S.A. · 1990
• Genomic organization of the retinoic acid receptor gamma gene. Nucleic Acids Res. · 1991
• … and 1 more in the literature graph