Retinoic acid receptor RXR-beta

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).

Classification

Family (Pfam)

PF00104 Hormone_recep, PF00105 zf-C4

InterPro

NHR-like_dom_sf, Nucl_hrmn_rcpt_lig-bd, Nuclear_hormone_rcpt_NR2, Nuclear_hrmn_rcpt, Retinoid-X_rcpt/HNF4, Znf_hrmn_rcpt, Znf_NHR/GATA

Functional cluster

Homeobox & Zinc-Finger Transcription Factors

Experimental structures · PDB · 7

• 1H9U X-ray 2.70A
• 1UHL X-ray 2.90A
• 5HJP X-ray 2.60A
• 5I4V X-ray 2.61A
• 5KYA X-ray 2.60A
• 5KYJ X-ray 2.80A
• 7A78 X-ray 1.72A

A predicted model is available from AlphaFold.

Gene Ontology · 24

• GO:0000785 chromatin
• GO:0005829 cytosol
• GO:0005730 nucleolus
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0090575 RNA polymerase II transcription regulator complex
• GO:0031490 chromatin DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0004879 nuclear receptor activity
• GO:0003707 nuclear steroid receptor activity
• GO:0044323 retinoic acid-responsive element binding
• GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
• GO:1990837 sequence-specific double-stranded DNA binding
• GO:0008270 zinc ion binding
• GO:0030154 cell differentiation
• GO:0071300 cellular response to retinoic acid
• GO:0009755 hormone-mediated signaling pathway
• GO:0042789 mRNA transcription by RNA polymerase II
• GO:0007399 nervous system development
• GO:0030501 positive regulation of bone mineralization
• GO:0045893 positive regulation of DNA-templated transcription
• GO:0045944 positive regulation of transcription by RNA polymerase II
• GO:0048384 retinoic acid receptor signaling pathway

Drugs targeting this protein · 6

• BEXAROTENE agonist
• ACITRETIN agonist
• MOFAROTENE modulator
• ETRETINATE agonist
• ALITRETINOIN agonist
• IRX-4204 agonist

Related proteins · sequence + function similarity

• Retinoic acid receptor RXR-beta 1.00
• Retinoic acid receptor RXR-beta 0.99
• Retinoic acid receptor RXR-beta 0.96
• Oxysterols receptor LXR-beta 0.84
• Oxysterols receptor LXR-beta 0.82
• Retinoic acid receptor RXR-beta-A 0.81
• Nuclear receptor subfamily 2 group F member 6 0.80
• Retinoic acid receptor RXR 0.79
• Retinoic acid receptor RXR 0.78
• Steroid hormone receptor ERR1 0.78
• Steroid hormone receptor ERR1 0.78
• Steroid hormone receptor ERR1 0.78

Co-cited proteins · studied together in the literature

• Retinoic acid receptor RXR-alpha 2 shared papers
• Retinoic acid receptor RXR-beta 1 shared papers
• Retinoic acid receptor RXR-gamma 1 shared papers
• Retinoic acid receptor alpha 2 shared papers
• Retinoic acid receptor RXR-alpha 2 shared papers
• Retinoic acid receptor RXR-alpha 1 shared papers
• Vascular cell adhesion protein 1 1 shared papers
• Retinoic acid receptor gamma 1 shared papers
• Retinoic acid receptor RXR-gamma 1 shared papers
• Transcription factor GATA-6 1 shared papers
• Retinoic acid receptor beta 1 shared papers
• Krueppel-like factor 2 1 shared papers

Literature · 12 cited papers

• MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases. Proc. Natl. Acad. Sci. U.S.A. · 2017
• Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain · 2015
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol. Cell. Proteomics · 2014
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and analysis of human chromosome 6. Nature · 2003
• Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation. EMBO J. · 2003
• The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12. J. Biol. Chem. · 2002
• Cloning and chromosome mapping of human retinoid X receptor beta: selective amino acid sequence conservation of a nuclear hormone receptor in mammals. Hum. Genet. · 1993
• PMID 1330328 Cell · 1992
• Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor beta. Nucleic Acids Res. · 1992
• Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell · 1992