cAMP-dependent protein kinase catalytic subunit beta

UniProt P22694 Organism Homo sapiens Gene PRKACB EC 2.7.11.11

Also known as: PRKACB

Function

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR.

Classification

Family (Pfam): PF00069 Pkinase
InterPro: AGC-kinase_C, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS, STKc_PKA
Functional cluster: Protein Serine/Threonine Kinases

Gene Ontology · 23

Disease associations

cardioacrofacial dysplasia 2 MONDO:0030877

Drugs targeting this protein · 1

GSK-690693 inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

cAMP-dependent protein kinase catalytic subunit gamma 1 shared papers
G-patch domain and KOW motifs-containing protein 1 shared papers
cAMP-dependent protein kinase type II-beta regulatory subunit 2 shared papers
cAMP-dependent protein kinase catalytic subunit alpha 3 shared papers
E3 ubiquitin-protein ligase Praja-2 1 shared papers
cAMP-dependent protein kinase type II-beta regulatory subunit 1 shared papers
cAMP-dependent protein kinase type I-alpha regulatory subunit 2 shared papers
Regulatory-associated protein of mTOR 1 shared papers
E3 ubiquitin-protein ligase Praja-2 1 shared papers
cAMP-dependent protein kinase type II-alpha regulatory subunit 1 shared papers
Regulatory-associated protein of mTOR 1 shared papers
Serine/threonine-protein kinase mTOR 1 shared papers

Literature · 16 cited papers

Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. Am. J. Hum. Genet. · 2020
GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife · 2019
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat. Commun. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A. J. Mol. Signal. · 2011
Control of PKA stability and signalling by the RING ligase praja2. Nat. Cell Biol. · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
Patterns of somatic mutation in human cancer genomes. Nature · 2007
The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
… and 4 more in the literature graph

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