cAMP-dependent protein kinase catalytic subunit gamma

Function

Phosphorylates a large number of substrates in the cytoplasm and the nucleus.

Classification

Family (Pfam)

PF00069 Pkinase

InterPro

AGC-kinase_C, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS, STKc_PKA

Functional cluster

Serine/Threonine Protein Kinases

Gene Ontology · 18

• GO:0005952 cAMP-dependent protein kinase complex
• GO:0097546 ciliary base
• GO:0005829 cytosol
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0005524 ATP binding
• GO:0004691 cAMP-dependent protein kinase activity
• GO:0019870 potassium channel inhibitor activity
• GO:0034237 protein kinase A regulatory subunit binding
• GO:0106310 protein serine kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
• GO:0034380 high-density lipoprotein particle assembly
• GO:0008584 male gonad development
• GO:0032024 positive regulation of insulin secretion
• GO:0003091 renal water homeostasis
• GO:0007283 spermatogenesis
• GO:0097700 vascular endothelial cell response to laminar fluid shear stress

Disease associations

• platelet-type bleeding disorder 19 MONDO:0014518

Drugs targeting this protein · 1

• GSK-690693 inhibitor

Related proteins · sequence + function similarity

• cAMP-dependent protein kinase catalytic subunit beta 0.98
• cAMP-dependent protein kinase catalytic subunit beta 0.98
• cAMP-dependent protein kinase catalytic subunit beta 0.98
• cAMP-dependent protein kinase catalytic subunit beta 0.97
• cAMP-dependent protein kinase catalytic subunit 1 0.97
• cAMP-dependent protein kinase catalytic subunit beta 0.97
• cAMP-dependent protein kinase catalytic subunit beta 0.96
• cAMP-dependent protein kinase catalytic subunit alpha 0.96
• cAMP-dependent protein kinase catalytic subunit alpha 0.96
• cAMP-dependent protein kinase catalytic subunit alpha 0.96
• cAMP-dependent protein kinase catalytic subunit alpha 0.96
• cAMP-dependent protein kinase catalytic subunit alpha 0.96

Co-cited proteins · studied together in the literature

• cAMP-dependent protein kinase catalytic subunit gamma 1 shared papers
• cAMP-dependent protein kinase catalytic subunit beta 1 shared papers

Literature · 6 cited papers

• A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene. Blood · 2014
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• DNA sequence and analysis of human chromosome 9. Nature · 2004
• The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon. Genomics · 1998
• Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. Mol. Endocrinol. · 1990