Thyroid hormone receptor beta
Also known as: ERBA2, NR1A2, THR1, THRB
Function
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Classification
- Family (Pfam)
- PF00104 Hormone_recep, PF00105 zf-C4
- InterPro
- NHR-like_dom_sf, Nucl_hrmn_rcpt_lig-bd, Nuclear_hormone_rcpt_NR1, Nuclear_hrmn_rcpt, ThyrH_rcpt, Znf_hrmn_rcpt, Znf_NHR/GATA
- Functional cluster
- Zinc-Finger & Chromatin Regulatory Proteins
Experimental structures · PDB · 34
- 1BSX X-ray 3.70A
- 1N46 X-ray 2.20A
- 1NAX X-ray 2.70A
- 1NQ0 X-ray 2.40A
- 1NQ1 X-ray 2.90A
- 1NQ2 X-ray 2.40A
- 1NUO X-ray 3.10A
- 1Q4X X-ray 2.80A
- 1R6G X-ray 3.00A
- 1XZX X-ray 2.50A
- 1Y0X X-ray 3.10A
- 2J4A X-ray 2.20A
- … and 22 more
A predicted model is available from AlphaFold.
Gene Ontology · 25
- GO:0000785 chromatin
- GO:0016604 nuclear body
- GO:0005654 nucleoplasm
- GO:0005634 nucleus
- GO:0090575 RNA polymerase II transcription regulator complex
- GO:0031490 chromatin DNA binding
- GO:0003677 DNA binding
- GO:0003700 DNA-binding transcription factor activity
- GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0019899 enzyme binding
- GO:0004879 nuclear receptor activity
- GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
- GO:1990837 sequence-specific double-stranded DNA binding
- GO:0070324 thyroid hormone binding
- GO:0001223 transcription coactivator binding
- GO:0008270 zinc ion binding
- GO:0030154 cell differentiation
- GO:0097067 cellular response to thyroid hormone stimulus
- GO:0006351 DNA-templated transcription
- GO:0042789 mRNA transcription by RNA polymerase II
- GO:0000122 negative regulation of transcription by RNA polymerase II
- GO:0002157 positive regulation of thyroid hormone receptor signaling pathway
- GO:0045944 positive regulation of transcription by RNA polymerase II
- GO:0048384 retinoic acid receptor signaling pathway
- GO:0002154 thyroid hormone receptor signaling pathway
Disease associations
- selective pituitary resistance to thyroid hormone MONDO:0007784
- thyroid hormone resistance, generalized, autosomal dominant MONDO:0008569
- thyroid hormone resistance, generalized, autosomal recessive MONDO:0010131
Drugs targeting this protein · 9
- LIOTHYRONINE SODIUM agonist
- LIOTHYRONINE agonist
- EPROTIROME agonist
- LEVOTHYROXINE SODIUM agonist
- RESMETIROM agonist
- DEXTROTHYROXINE SODIUM agonist
- TIRATRICOL agonist
- MB07811 agonist
- DEXTROTHYROXINE agonist
Related proteins · sequence + function similarity
- Thyroid hormone receptor beta 0.98
- Thyroid hormone receptor beta 0.98
- Thyroid hormone receptor alpha 0.97
- Thyroid hormone receptor alpha-A 0.97
- Thyroid hormone receptor alpha 0.97
- Thyroid hormone receptor alpha 0.97
- Thyroid hormone receptor alpha 0.97
- Thyroid hormone receptor alpha 0.96
- Thyroid hormone receptor alpha 0.96
- Thyroid hormone receptor alpha 0.96
- Thyroid hormone receptor alpha-B 0.96
- Thyroid hormone receptor alpha 0.96
Co-cited proteins · studied together in the literature
- Thyroid hormone receptor alpha 6 shared papers
- Thyroid hormone-inducible hepatic protein 1 shared papers
- Nuclear receptor subfamily 2 group F member 6 1 shared papers
- Retinoic acid receptor RXR-alpha 3 shared papers
- Nuclear receptor coactivator 7 1 shared papers
- Nuclear receptor coactivator 7 1 shared papers
- Peroxisome proliferator-activated receptor gamma 3 shared papers
- Thyroid hormone receptor beta 1 shared papers
- Retinoic acid receptor alpha 3 shared papers
- Transforming acidic coiled-coil-containing protein 1 1 shared papers
- Estrogen receptor 3 shared papers
- Progesterone receptor 1 shared papers
Literature · 42 cited papers
- The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR. BMC Mol. Biol. · 2010
- Gaining ligand selectivity in thyroid hormone receptors via entropy. Proc. Natl. Acad. Sci. U.S.A. · 2009
- Genotyping of resistance to thyroid hormone in South American population. Identification of seven novel missense mutations in the human thyroid hormone receptor beta gene. Mol. Cell. Probes · 2009
- Molecular basis for dimer formation of TRbeta variant D355R. Proteins · 2009
- Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms. BMC Struct. Biol. · 2008
- Human spot 14 protein interacts physically and functionally with the thyroid receptor. Biochem. Biophys. Res. Commun. · 2007
- Mosaicism of a thyroid hormone receptor-beta gene mutation in resistance to thyroid hormone. J. Clin. Endocrinol. Metab. · 2006
- Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function. J. Mol. Biol. · 2006
- The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Thyroxine-thyroid hormone receptor interactions. J. Biol. Chem. · 2004
- Multiple messenger ribonucleic acid variants regulate cell-specific expression of human thyroid hormone receptor beta1. Mol. Endocrinol. · 2004
- … and 30 more in the literature graph
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