Progesterone receptor

Function

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor.

Classification

Family (Pfam)

PF00104 Hormone_recep, PF02161 Prog_receptor, PF00105 zf-C4

InterPro

NHR-like_dom_sf, Nucl_hrmn_rcpt_lig-bd, Nuclear_hormone_rcpt_NR3, Nuclear_hrmn_rcpt, Progest_rcpt, Znf_hrmn_rcpt, Znf_NHR/GATA

Functional cluster

Homeobox & Zinc-Finger Transcription Factors

Experimental structures · PDB · 20

• 1A28 X-ray 1.80A
• 1E3K X-ray 2.80A
• 1SQN X-ray 1.45A
• 1SR7 X-ray 1.46A
• 1ZUC X-ray 2.00A
• 2C7A X-ray 2.50A
• 2OVH X-ray 2.00A
• 2OVM X-ray 2.60A
• 2W8Y X-ray 1.80A
• 3D90 X-ray 2.26A
• 3G8O X-ray 1.90A
• 3HQ5 X-ray 2.10A
• … and 8 more

A predicted model is available from AlphaFold.

Gene Ontology · 32

• GO:0000785 chromatin
• GO:0005829 cytosol
• GO:0005741 mitochondrial outer membrane
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0005886 plasma membrane
• GO:0051117 ATPase binding
• GO:0003677 DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0019899 enzyme binding
• GO:0034056 estrogen response element binding
• GO:0042802 identical protein binding
• GO:0004879 nuclear receptor activity
• GO:0003707 nuclear steroid receptor activity
• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0005102 signaling receptor binding
• GO:0005496 steroid binding
• GO:0001223 transcription coactivator binding
• GO:0008270 zinc ion binding
• GO:0007267 cell-cell signaling
• GO:0006351 DNA-templated transcription
• GO:0051457 maintenance of protein location in nucleus
• GO:0010629 negative regulation of gene expression
• GO:0042326 negative regulation of phosphorylation
• GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway
• GO:0010628 positive regulation of gene expression
• GO:0045944 positive regulation of transcription by RNA polymerase II
• GO:0050847 progesterone receptor signaling pathway
• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II
• GO:0007165 signal transduction

Drugs targeting this protein · 33

• PROGESTERONE agonist
• CHLORMADINONE ACETATE modulator
• NORETHINDRONE agonist
• ETHYNODIOL DIACETATE agonist
• NORELGESTROMIN agonist
• HYDROXYPROGESTERONE CAPROATE agonist
• DYDROGESTERONE agonist
• NORGESTIMATE agonist
• MEGESTROL ACETATE agonist
• NORETHINDRONE ACETATE agonist
• GESTODENE agonist
• MIFEPRISTONE antagonist
• NORETHYNODREL agonist
• LEVONORGESTREL agonist
• CYPROTERONE ACETATE agonist
• LONAPRISAN antagonist
• NOMEGESTROL ACETATE agonist
• DANAZOL agonist
• DROSPIRENONE agonist
• ETONOGESTREL agonist
• DESOGESTREL agonist
• ONAPRISTONE antagonist
• ULIPRISTAL modulator
• TRIMEGESTONE agonist
• TELAPRISTONE ACETATE modulator
• NOMEGESTROL agonist
• NORGESTREL agonist
• ULIPRISTAL ACETATE modulator
• ASOPRISNIL modulator
• ALLYLESTRENOL agonist
• SEGESTERONE ACETATE agonist
• VILAPRISAN modulator
• MEDROXYPROGESTERONE ACETATE agonist

Related proteins · sequence + function similarity

• Progesterone receptor 1.00
• Progesterone receptor 1.00
• Progesterone receptor 1.00
• Progesterone receptor 1.00
• Progesterone receptor 0.99
• Progesterone receptor 0.99
• Progesterone receptor 0.99
• Progesterone receptor 0.99
• Progesterone receptor 0.99
• Progesterone receptor 0.99
• Progesterone receptor 0.99
• Progesterone receptor 0.99

Co-cited proteins · studied together in the literature

• CUE domain-containing protein 2 1 shared papers
• Protein unc-45 homolog A 1 shared papers
• Estrogen receptor 6 shared papers
• Palmitoyltransferase ZDHHC21 1 shared papers
• COUP transcription factor 1 1 shared papers
• Glucocorticoid receptor 2 shared papers
• Palmitoyltransferase ZDHHC7 1 shared papers
• Transcription initiation factor IIB 1 shared papers
• Oxysterols receptor LXR-alpha 1 shared papers
• Progesterone receptor 1 shared papers
• Progesterone receptor 1 shared papers
• Progesterone receptor 1 shared papers

Literature · 37 cited papers

• UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Mol. Cell · 2023
• A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration. Mol. Endocrinol. · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. Mol. Biol. Cell · 2012
• The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor. Mol. Phylogenet. Evol. · 2008
• Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors. Mol. Endocrinol. · 2008
• Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells. Mol. Endocrinol. · 2007
• CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. EMBO J. · 2007
• Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth. Steroids · 2007
• PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus. Nucleic Acids Res. · 2006
• Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
• GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Mol. Cell. Biol. · 2006
• … and 25 more in the literature graph