Sphingosine 1-phosphate receptor 2

Function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Receptor for the chemokine-like protein FAM19A5. Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). In lymphoid follicles, couples the binding of S1P to the activation of GNA13 and downstream inhibition of AKT activation leading to suppression of germinal center (GC) B cell growth and migration outside the GC niche.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

EDG5_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, S1P_rcpt

Functional cluster

Membrane Channels & Lipid-Anchored Proteins

Experimental structures · PDB · 1

• 7T6B EM 3.19A

A predicted model is available from AlphaFold.

Gene Ontology · 18

• GO:0005737 cytoplasm
• GO:0098978 glutamatergic synapse
• GO:0005886 plasma membrane
• GO:0098793 presynapse
• GO:0008528 G protein-coupled peptide receptor activity
• GO:0004930 G protein-coupled receptor activity
• GO:0001664 G protein-coupled receptor binding
• GO:0005178 integrin binding
• GO:0008289 lipid binding
• GO:0038036 sphingosine-1-phosphate receptor activity
• GO:0030036 actin cytoskeleton organization
• GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
• GO:0046847 filopodium assembly
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0008284 positive regulation of cell population proliferation
• GO:1903142 positive regulation of establishment of endothelial barrier
• GO:0150052 regulation of postsynapse assembly
• GO:0003376 sphingosine-1-phosphate receptor signaling pathway

Disease associations

• autosomal recessive nonsyndromic hearing loss 68 MONDO:0012485

Drugs targeting this protein · 3

• AMISELIMOD HYDROCHLORIDE modulator
• FINGOLIMOD LAURYL SULFATE binding agent
• FINGOLIMOD HYDROCHLORIDE agonist

Related proteins · sequence + function similarity

• Sphingosine 1-phosphate receptor 2 0.99
• Sphingosine 1-phosphate receptor 2 0.99
• Lysophosphatidic acid receptor 2 0.90
• Lysophosphatidic acid receptor 2 0.89
• Lysophosphatidic acid receptor 2 0.89
• Sphingosine 1-phosphate receptor 4 0.89
• Cannabinoid receptor 2 0.88
• Cannabinoid receptor 2 0.88
• Cannabinoid receptor 2 0.87
• Sphingosine 1-phosphate receptor 3 0.87
• Lysophosphatidic acid receptor 3 0.85
• Sphingosine 1-phosphate receptor 4 0.85

Co-cited proteins · studied together in the literature

• Sphingosine 1-phosphate receptor 3 1 shared papers
• Chemokine-like protein TAFA-5 1 shared papers
• Chemokine-like protein TAFA-5 1 shared papers
• Sphingosine 1-phosphate receptor 2 1 shared papers
• Chemokine-like protein TAFA-5 1 shared papers
• Rho guanine nucleotide exchange factor 1 1 shared papers
• S-geranylgeranyl-glutathione receptor P2RY8 1 shared papers
• Guanine nucleotide-binding protein subunit alpha-13 1 shared papers
• Guanine nucleotide-binding protein subunit alpha-13 1 shared papers

Literature · 5 cited papers

• Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2. Circulation · 2018
• Autosomal-recessive hearing impairment due to rare missense variants within S1PR2. Am. J. Hum. Genet. · 2016
• Loss of signalling via Galpha13 in germinal centre B-cell-derived lymphoma. Nature · 2014
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. J. Biol. Chem. · 2000