Sphingosine 1-phosphate receptor 3
Also known as: C9orf108, C9orf47, EDG3, S1PR3
Function
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- EDG3_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, S1P_rcpt
- Functional cluster
- MFS & Drug-Efflux Transporters
Experimental structures · PDB · 6
A predicted model is available from AlphaFold.
Gene Ontology · 14
- GO:0005737 cytoplasm
- GO:0005886 plasma membrane
- GO:0098793 presynapse
- GO:0004930 G protein-coupled receptor activity
- GO:0005178 integrin binding
- GO:0008289 lipid binding
- GO:0038036 sphingosine-1-phosphate receptor activity
- GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:0009653 anatomical structure morphogenesis
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0006954 inflammatory response
- GO:1903141 negative regulation of establishment of endothelial barrier
- GO:0008284 positive regulation of cell population proliferation
- GO:0007204 positive regulation of cytosolic calcium ion concentration
Drugs targeting this protein · 3
- AMISELIMOD HYDROCHLORIDE modulator
- FINGOLIMOD LAURYL SULFATE binding agent
- FINGOLIMOD HYDROCHLORIDE agonist
Related proteins · sequence + function similarity
- Sphingosine 1-phosphate receptor 3 0.99
- Sphingosine 1-phosphate receptor 1 0.95
- Sphingosine 1-phosphate receptor 1 0.95
- Sphingosine 1-phosphate receptor 1 0.94
- Sphingosine 1-phosphate receptor 3 0.94
- Sphingosine 1-phosphate receptor 1 0.94
- Sphingosine 1-phosphate receptor 1 0.94
- Sphingosine 1-phosphate receptor 2 0.89
- Sphingosine 1-phosphate receptor 2 0.87
- Sphingosine 1-phosphate receptor 2 0.86
- Sphingosine 1-phosphate receptor 2 0.84
- Lysophosphatidic acid receptor 3 0.83
Co-cited proteins · studied together in the literature
- Sphingosine 1-phosphate receptor 2 2 shared papers
- Sphingosine 1-phosphate receptor 2 1 shared papers
- Sphingosine 1-phosphate receptor 1 2 shared papers
Literature · 9 cited papers
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- DNA sequence and analysis of human chromosome 9. Nature · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes. Mol. Pharmacol. · 2000
- Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. J. Biol. Chem. · 2000
- Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. J. Biol. Chem. · 1999
- Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. FEBS Lett. · 1997
- Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. Biochem. Biophys. Res. Commun. · 1996
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