Cannabinoid receptor 2

UniProt P34972 Organism Homo sapiens Gene CB2A, CB2B, CNR2

Also known as: CB2A, CB2B, CNR2

Function

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Classification

Family (Pfam): PF00001 7tm_1
InterPro: Canbinoid_rcpt_2, Cnbnoid_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
Functional cluster: Membrane Channels & Lipid-Anchored Proteins

Experimental structures · PDB · 10

2KI9 NMR
5ZTY X-ray 2.80A
6KPC X-ray 3.20A
6KPF EM 2.90A
6PT0 EM 3.20A
8GUQ EM 3.08A
8GUR EM 2.84A
8GUS EM 2.97A
8GUT EM 2.98A
8X3L EM 3.13A

A predicted model is available from AlphaFold.

Gene Ontology · 19

Drugs targeting this protein · 8

S-777469 agonist
NONABINE agonist
GW842166X agonist
SAD448 agonist
LY2828360 agonist
PRS-211375 agonist
TEDALINAB agonist
OLORINAB agonist

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Cannabinoid receptor 2 2 shared papers
Cannabinoid receptor 2 2 shared papers
C-C motif chemokine 2 1 shared papers
Interleukin-1 beta 1 shared papers
Interleukin-6 1 shared papers
Cannabinoid receptor 1 1 shared papers
Cannabinoid receptor 1 1 shared papers
C-C motif chemokine 2 1 shared papers
Cannabinoid receptor 1 1 shared papers
Interleukin-18 1 shared papers
Interleukin-1 beta 1 shared papers
Apoptosis-associated speck-like protein containing a CARD 1 shared papers

Literature · 19 cited papers

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat. Med. · 2013
Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. Genes Brain Behav. · 2009
Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments. Biochem. Biophys. Res. Commun. · 2009
Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons. Pain · 2008
Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. PLoS ONE · 2008
The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. Synapse · 2004
Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. J. Neurosci. · 2003
2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. J. Biol. Chem. · 2003
Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor. Biochem. Pharmacol. · 2003
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J. Clin. Invest. · 2003
… and 7 more in the literature graph

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