Glucose-dependent insulinotropic receptor
Also known as: GPR119
Function
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, GPR119
- Functional cluster
- MFS & Drug-Efflux Transporters
Experimental structures · PDB · 9
- 7WCM EM 2.33A
- 7WCN EM 2.87A
- 7XZ5 EM 3.10A
- 7XZ6 EM 2.80A
- 8VHF EM 3.51A
- 8ZR5 EM 3.31A
- 8ZRK EM 2.82A
- 9L79 EM 2.98A
- 9L80 EM 3.33A
A predicted model is available from AlphaFold.
Gene Ontology · 6
Drugs targeting this protein · 2
- GSK-1292263 agonist
- MBX-2982 agonist
Related proteins · sequence + function similarity
- Glucose-dependent insulinotropic receptor 0.99
- Cannabinoid receptor 2 0.89
- Cannabinoid receptor 2 0.89
- Melanocyte-stimulating hormone receptor 0.88
- Melanocyte-stimulating hormone receptor 0.88
- Cannabinoid receptor 2 0.88
- Melanocyte-stimulating hormone receptor 0.88
- Melanocyte-stimulating hormone receptor 0.88
- Melanocyte-stimulating hormone receptor 0.88
- Melanocyte-stimulating hormone receptor 0.88
- Melanocyte-stimulating hormone receptor 0.88
- Melanocyte-stimulating hormone receptor 0.88
Co-cited proteins · studied together in the literature
- Glucose-dependent insulinotropic receptor 2 shared papers
- Glucose-dependent insulinotropic receptor 2 shared papers
- G protein-coupled receptor 135 1 shared papers
- G protein-coupled receptor 135 1 shared papers
- Probable G protein-coupled receptor 141 1 shared papers
- Relaxin-3 receptor 2 1 shared papers
- Probable G protein-coupled receptor 141 1 shared papers
- G protein-coupled receptor 135 1 shared papers
- Relaxin-3 receptor 2 2 shared papers
- Opsin-5 1 shared papers
- G protein-coupled receptor 142 1 shared papers
- G protein-coupled receptor 142 1 shared papers
Literature · 6 cited papers
- Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. · 2006
- The DNA sequence of the human X chromosome. Nature · 2005
- Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem. Biophys. Res. Commun. · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. · 2003
- Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett. · 2002
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