lmmol · Proteins

Voltage-dependent T-type calcium channel subunit alpha-1G

UniProt O43497 Organism Homo sapiens Gene CACNA1G, KIAA1123

Also known as: CACNA1G, KIAA1123

Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Classification

Family (Pfam)
PF00520 Ion_trans
InterPro
Ion_trans_dom, VDCC_alpha-1_subunit, VDCC_T_a1, VDCCAlpha1, Volt_channel_dom_sf
Functional cluster
Homeobox & Zinc-Finger Transcription Factors

Experimental structures · PDB · 2

A predicted model is available from AlphaFold.

Gene Ontology · 22

Disease associations

Drugs targeting this protein · 17

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 13 cited papers

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