lmmol · Proteins

Voltage-dependent T-type calcium channel subunit alpha-1I

UniProt Q9P0X4 Organism Homo sapiens Gene CACNA1I, KIAA1120

Also known as: CACNA1I, KIAA1120

Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H.

Classification

Family (Pfam)
PF00520 Ion_trans
InterPro
Ion_trans_dom, VDCC_alpha-1_subunit, VDCC_T_a1, VDCCAlpha1, Volt_channel_dom_sf
Functional cluster
G Protein-Coupled Receptors

Experimental structures · PDB · 4

A predicted model is available from AlphaFold.

Gene Ontology · 6

Disease associations

Drugs targeting this protein · 17

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 8 cited papers

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