lmmol · Proteins

Sodium channel protein type 5 subunit alpha

UniProt Q14524 Organism Homo sapiens Gene SCN5A

Also known as: SCN5A

Function

Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat. Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity).

Classification

Family (Pfam)
PF00520 Ion_trans, PF24609 IQ_SCN5A_C, PF06512 Na_trans_assoc, PF11933 Na_trans_cytopl
InterPro
Ion_trans_dom, IQ_SCN5A_C, Na_channel_a5su, Na_channel_asu, Na_chnl_inactivation_gate, Na_trans_assoc_dom, Na_trans_cytopl, VGCC_Ca_Na, Volt_channel_dom_sf
Functional cluster
Membrane Transporters & GPCRs

Experimental structures · PDB · 14

A predicted model is available from AlphaFold.

Gene Ontology · 65

Disease associations

Drugs targeting this protein · 62

Neighborhood · nearest proteins

SCN5AScn5aScn5aSCN10AGPD1LMOG1ERG
Nearest neighbours of Sodium channel protein type 5 subunit alpha: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 111 cited papers

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