Sodium channel protein type 10 subunit alpha
Also known as: SCN10A
Function
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
Classification
- Family (Pfam)
- PF00520 Ion_trans, PF24609 IQ_SCN5A_C, PF06512 Na_trans_assoc
- InterPro
- Ion_trans_dom, IQ_SCN5A_C, Na_channel_asu, Na_chnl_inactivation_gate, Na_trans_assoc_dom, VGCC_Ca_Na, Volt_channel_dom_sf
- Functional cluster
- Membrane Transporters & GPCRs
Experimental structures · PDB · 8
- 7WE4 EM 2.70A
- 7WEL EM 3.20A
- 7WFR EM 3.00A
- 7WFW EM 3.10A
- 9DBK EM 3.12A
- 9DBL EM 3.24A
- 9DBM EM 3.22A
- 9DBN EM 2.76A
A predicted model is available from AlphaFold.
Gene Ontology · 21
- GO:0030424 axon
- GO:0071439 clathrin complex
- GO:0070062 extracellular exosome
- GO:0098978 glutamatergic synapse
- GO:0005886 plasma membrane
- GO:0042734 presynaptic membrane
- GO:0001518 voltage-gated sodium channel complex
- GO:0044325 transmembrane transporter binding
- GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
- GO:0005248 voltage-gated sodium channel activity
- GO:0086016 AV node cell action potential
- GO:0086043 bundle of His cell action potential
- GO:0086002 cardiac muscle cell action potential involved in contraction
- GO:0086010 membrane depolarization during action potential
- GO:0042475 odontogenesis of dentin-containing tooth
- GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
- GO:0055117 regulation of cardiac muscle contraction
- GO:0002027 regulation of heart rate
- GO:0034765 regulation of monoatomic ion transmembrane transport
- GO:0007600 sensory perception
- GO:0035725 sodium ion transmembrane transport
Disease associations
- episodic pain syndrome, familial, 2 MONDO:0014246
Drugs targeting this protein · 59
- OXCARBAZEPINE blocker
- CARBAMAZEPINE blocker
- ETHOTOIN blocker
- PRILOCAINE blocker
- MORICIZINE HYDROCHLORIDE blocker
- INDECAINIDE HYDROCHLORIDE blocker
- ORPHENADRINE CITRATE blocker
- LIDOCAINE HYDROCHLORIDE blocker
- QUINIDINE GLUCONATE blocker
- MEPIVACAINE HYDROCHLORIDE blocker
- PROPARACAINE HYDROCHLORIDE blocker
- DYCLONINE HYDROCHLORIDE blocker
- PRILOCAINE HYDROCHLORIDE blocker
- ETIDOCAINE HYDROCHLORIDE blocker
- MEXILETINE HYDROCHLORIDE blocker
- DIBUCAINE HYDROCHLORIDE blocker
- BENOXINATE HYDROCHLORIDE blocker
- HEXYLCAINE HYDROCHLORIDE blocker
- TOCAINIDE HYDROCHLORIDE blocker
- ARTICAINE HYDROCHLORIDE blocker
- PROCAINE HYDROCHLORIDE blocker
- DISOPYRAMIDE PHOSPHATE blocker
- PHENAZOPYRIDINE HYDROCHLORIDE blocker
- ORPHENADRINE HYDROCHLORIDE blocker
- PROPAFENONE HYDROCHLORIDE blocker
- DRONEDARONE HYDROCHLORIDE blocker
- RUFINAMIDE blocker
- TETRACAINE HYDROCHLORIDE blocker
- PHENYTOIN blocker
- PHENYTOIN SODIUM blocker
- PROPOXYCAINE HYDROCHLORIDE blocker
- ROPIVACAINE HYDROCHLORIDE blocker
- ENCAINIDE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- RALFINAMIDE blocker
- TOPIRAMATE blocker
- IRAMPANEL blocker
- ESLICARBAZEPINE blocker
- DICHLOROBENZYL ALCOHOL blocker
- AFACIFENACIN blocker
- PF-04531083 blocker
- EVENAMIDE blocker
- QUINIDINE SULFATE blocker
- CENOBAMATE inhibitor
- DSP-2230 blocker
- COCAINE HYDROCHLORIDE blocker
- LACOSAMIDE blocker
- PROCAINAMIDE HYDROCHLORIDE blocker
- TETRACAINE blocker
- LAMOTRIGINE blocker
- RILUZOLE blocker
- ZONISAMIDE blocker
- LIDOCAINE blocker
- PRIMIDONE blocker
- MEPHENYTOIN blocker
- ESLICARBAZEPINE ACETATE blocker
- PHENACEMIDE blocker
- FOSPHENYTOIN SODIUM blocker
- CHLOROPROCAINE HYDROCHLORIDE blocker
Related proteins · sequence + function similarity
- Sodium channel protein type 10 subunit alpha 0.98
- Sodium channel protein type 10 subunit alpha 0.97
- Sodium channel protein type 10 subunit alpha 0.95
- Sodium channel protein type 5 subunit alpha 0.95
- Sodium channel protein type 10 subunit alpha 0.95
- Sodium channel protein type 5 subunit alpha 0.94
- Sodium channel protein type 11 subunit alpha 0.94
- Sodium channel protein type 5 subunit alpha 0.93
- Sodium channel protein type 11 subunit alpha 0.93
- Sodium channel protein type 11 subunit alpha 0.92
- Sodium channel protein type 4 subunit alpha 0.91
- Sodium channel protein type 4 subunit alpha 0.90
Literature · 4 cited papers
- Gain-of-function Nav1.8 mutations in painful neuropathy. Proc. Natl. Acad. Sci. U.S.A. · 2012
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature · 2011
- The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
- A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. Pain · 1998
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