lmmol · Proteins

Gamma-aminobutyric acid receptor subunit delta

UniProt O14764 Organism Homo sapiens Gene GABRD

Also known as: GABRD

Function

Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing delta/GABRD subunits are predominantly located in extrasynaptic or perisynaptic positions on hippocampus and cerebellar granule cells, and contribute to the tonic GABAergic inhibition (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness.

Classification

Family (Pfam)
PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb
InterPro
GABAA/Glycine_rcpt, GABAAd_rcpt, Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS
Functional cluster
Cytochrome P450 & Heme Enzymes

Experimental structures · PDB · 7

A predicted model is available from AlphaFold.

Gene Ontology · 17

Disease associations

Drugs targeting this protein · 67

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 6 cited papers

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