Proteasome subunit beta type-11
Also known as: PSMB11
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity).
Classification
- Family (Pfam)
- PF00227 Proteasome
- InterPro
- Ntn_hydrolases_N, Pept_T1A_subB, Proteasome_bsu_CS, Proteasome_sua/b, Proteasome_suB-type
- Functional cluster
- Zinc-Finger & Ubiquitination Proteins
Gene Ontology · 12
- GO:0005829 cytosol
- GO:0005634 nucleus
- GO:0019774 proteasome core complex, beta-subunit complex
- GO:0004175 endopeptidase activity
- GO:0008233 peptidase activity
- GO:0004298 threonine-type endopeptidase activity
- GO:0043374 CD8-positive, alpha-beta T cell differentiation
- GO:0160165 CD8-positive, alpha-beta T cell homeostasis
- GO:0010498 proteasomal protein catabolic process
- GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0006508 proteolysis
- GO:0045061 thymic T cell selection
Drugs targeting this protein · 7
- OPROZOMIB inhibitor
- IXAZOMIB inhibitor
- BORTEZOMIB inhibitor
- IXAZOMIB CITRATE inhibitor
- MARIZOMIB inhibitor
- CARFILZOMIB inhibitor
- BORTEZOMIB D-MANNITOL inhibitor
Related proteins · sequence + function similarity
- Proteasome subunit beta type-11 0.97
- Proteasome subunit beta type-8 0.86
- Proteasome subunit beta type-8 0.85
- Proteasome subunit beta type-8 0.84
- Proteasome subunit beta type-8 0.83
- Proteasome subunit beta type-8 0.83
- Proteasome subunit beta type-5 0.81
- Proteasome subunit beta type-6 0.79
- Proteasome subunit beta type-5 0.79
- Proteasome subunit beta type-6 0.78
- Proteasome subunit beta type-6 0.78
- Proteasome subunit beta type-5 0.78
Co-cited proteins · studied together in the literature
- Proteasome subunit beta type-11 1 shared papers
Literature · 2 cited papers
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