Lymphocyte antigen 96

UniProt Q9Y6Y9 Organism Homo sapiens Gene ESOP1, LY96, MD2

Also known as: ESOP1, LY96, MD2

Function

Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS.

Classification

Family (Pfam): PF02221 E1_DerP2_DerF2
InterPro: Ig_E-set, LY96, ML_dom
Functional cluster: Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 9

2E56 X-ray 2.00A
2E59 X-ray 2.21A
2Z65 X-ray 2.70A
3FXI X-ray 3.10A
3ULA X-ray 3.60A
4G8A X-ray 2.40A
8WO1 EM 2.24A
8WTA EM 2.90A
9J03 EM 2.70A

A predicted model is available from AlphaFold.

Gene Ontology · 19

Drugs targeting this protein · 1

ERITORAN TETRASODIUM antagonist

Related proteins · sequence + function similarity

Lymphocyte antigen 96 0.94
Lymphocyte antigen 96 0.93
Lymphocyte antigen 96 0.91
Lymphocyte antigen 86 0.82
Lymphocyte antigen 86 0.81
Lymphocyte antigen 86 0.76
MD-2-related lipid-recognition protein 0.75
MD-2-related lipid-recognition protein ROSY1 0.72
Mite group 2 allergen-like Ixo r 2 0.68
Putative protein heh-1 0.65
Mite group 2 allergen Der p 2 0.64
Ganglioside GM2 activator 0.64

Co-cited proteins · studied together in the literature

Lymphocyte antigen 96 1 shared papers
Lymphocyte antigen 96 2 shared papers
Monocyte differentiation antigen CD14 2 shared papers
Toll-like receptor 4 3 shared papers
Toll-like receptor 4 1 shared papers
Myeloid differentiation primary response protein MyD88 1 shared papers
Myeloid differentiation primary response protein MyD88 1 shared papers
Myeloid differentiation primary response protein MyD88 1 shared papers
Myeloid differentiation primary response protein MyD88 1 shared papers
Myeloid differentiation primary response protein MyD88 1 shared papers
Myeloid differentiation primary response protein MyD88 1 shared papers
Toll-like receptor 10 1 shared papers

Literature · 12 cited papers

Natural selection in the TLR-related genes in the course of primate evolution. Immunogenetics · 2008
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell · 2007
Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. Science · 2007
DNA sequence and analysis of human chromosome 8. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
The role of disulfide bonds in the assembly and function of MD-2. Proc. Natl. Acad. Sci. U.S.A. · 2003
Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4. Proc. Natl. Acad. Sci. U.S.A. · 2001
Molecular genetic analysis of an endotoxin nonresponder mutant cell line. A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. J. Exp. Med. · 2001
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J. Biol. Chem. · 2001
MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components. J. Immunol. · 2001
ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice. Blood · 2000
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. · 1999

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