Voltage-gated delayed rectifier potassium channel KCNH4
Also known as: KCNH4
Function
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier. Activates at more negative voltages, exhibits fast prepulse-independent activation kinetics and deactivates much more slowly, but shows no inactivation (By similarity).
Classification
- Family (Pfam)
- PF00520 Ion_trans, PF13426 PAS_9
- InterPro
- cNMP-bd_dom, cNMP-bd_dom_sf, Ion_trans_dom, K_chnl_volt-dep_EAG/ELK/ERG, K_chnl_volt-dep_ELK, KCNH_animal-type, PAC, PAS, PAS-assoc_C, PAS-like_dom_sf, RmlC-like_jellyroll
- Functional cluster
- Eukaryotic Transcription Factors & related
Gene Ontology · 6
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Voltage-gated inwardly rectifying potassium channel KCNH3 0.93
- Voltage-gated delayed rectifier potassium channel KCNH4 0.93
- Voltage-gated inwardly rectifying potassium channel KCNH3 0.91
- Voltage-gated inwardly rectifying potassium channel KCNH3 0.91
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.80
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.77
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.76
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.74
- Voltage-gated inwardly rectifying potassium channel KCNH6 0.74
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.72
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.72
- Voltage-gated inwardly rectifying potassium channel KCNH6 0.71
Co-cited proteins · studied together in the literature
- Voltage-gated inwardly rectifying potassium channel KCNH3 1 shared papers
- Voltage-gated delayed rectifier potassium channel KCNH4 1 shared papers
- Voltage-gated inwardly rectifying potassium channel KCNH3 1 shared papers
Literature · 2 cited papers
- The consensus coding sequences of human breast and colorectal cancers. Science · 2006
- New ether-a-go-go K+ channel family members localized in human telencephalon. J. Biol. Chem. · 1999
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