Voltage-gated inwardly rectifying potassium channel KCNH3
Also known as: KCNH3, KIAA1282
Function
Pore-forming (alpha) subunit of a voltage-gated inwardly rectifying potassium channel. Charactherized by a fast rate of activation during depolarization followed by a rapid inactivation at much more depolarized value causing inward rectification due to a C-type inactivation mechanism. Exhibits a rapid recovery from inactivation.
Classification
- Family (Pfam)
- PF00027 cNMP_binding, PF00520 Ion_trans, PF13426 PAS_9
- InterPro
- cNMP-bd_dom, cNMP-bd_dom_sf, Ion_trans_dom, K_chnl_volt-dep_EAG/ELK/ERG, K_chnl_volt-dep_ELK, KCNH_animal-type, PAC, PAS, PAS-assoc_C, PAS-like_dom_sf, RmlC-like_jellyroll
- Functional cluster
- Secreted Growth Factors & Cytokines
Gene Ontology · 8
- GO:0016020 membrane
- GO:0034702 monoatomic ion channel complex
- GO:0005886 plasma membrane
- GO:0005242 inward rectifier potassium channel activity
- GO:0005249 voltage-gated potassium channel activity
- GO:0071805 potassium ion transmembrane transport
- GO:0006813 potassium ion transport
- GO:0042391 regulation of membrane potential
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Voltage-gated inwardly rectifying potassium channel KCNH3 0.98
- Voltage-gated inwardly rectifying potassium channel KCNH3 0.98
- Voltage-gated delayed rectifier potassium channel KCNH4 0.93
- Voltage-gated delayed rectifier potassium channel KCNH4 0.92
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.81
- Voltage-gated inwardly rectifying potassium channel KCNH6 0.81
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.80
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.79
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.77
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.77
- Voltage-gated inwardly rectifying potassium channel KCNH6 0.76
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.75
Co-cited proteins · studied together in the literature
- Voltage-gated delayed rectifier potassium channel KCNH4 1 shared papers
- Voltage-gated delayed rectifier potassium channel KCNH4 1 shared papers
- Voltage-gated inwardly rectifying potassium channel KCNH3 1 shared papers
Literature · 2 cited papers
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