Voltage-gated inwardly rectifying potassium channel KCNH6
Also known as: ERG2, KCNH6
Function
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Activates even more slowly than KCNH2.
Classification
- Family (Pfam)
- PF00027 cNMP_binding, PF00520 Ion_trans, PF13426 PAS_9
- InterPro
- cNMP-bd_dom, cNMP-bd_dom_sf, Ion_trans_dom, K_chnl_volt-dep_EAG/ELK/ERG, K_chnl_volt-dep_ERG, KCNH_animal-type, PAS, PAS-like_dom_sf, RmlC-like_jellyroll
- Functional cluster
- Serine/Threonine Protein Kinases
Gene Ontology · 7
- GO:0034702 monoatomic ion channel complex
- GO:0005886 plasma membrane
- GO:0005242 inward rectifier potassium channel activity
- GO:0086013 membrane repolarization during cardiac muscle cell action potential
- GO:0071805 potassium ion transmembrane transport
- GO:0086091 regulation of heart rate by cardiac conduction
- GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Voltage-gated inwardly rectifying potassium channel KCNH6 0.96
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.87
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.87
- Voltage-gated delayed rectifier potassium channel KCNH4 0.87
- Voltage-gated inwardly rectifying potassium channel KCNH3 0.85
- Voltage-gated inwardly rectifying potassium channel KCNH3 0.84
- Voltage-gated inwardly rectifying potassium channel KCNH3 0.81
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.81
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.81
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.81
- Voltage-gated delayed rectifier potassium channel KCNH8 0.80
- Voltage-gated inwardly rectifying potassium channel KCNH2 0.79
Co-cited proteins · studied together in the literature
- Voltage-gated inwardly rectifying potassium channel KCNH7 1 shared papers
Literature · 5 cited papers
- A strategy for precise and large scale identification of core fucosylated glycoproteins. Mol. Cell. Proteomics · 2009
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- HERG K(+) currents in human prolactin-secreting adenoma cells. Pflugers Arch. · 2003
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.