Voltage-gated inwardly rectifying potassium channel KCNH7
Also known as: ERG3, KCNH7
Function
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Exhibits faster activation and deactivation kinetics and slow inactivation at membrane potentials positive to 240 mV, resulting in the weakest inward rectification.
Classification
- Family (Pfam)
- PF00027 cNMP_binding, PF00520 Ion_trans, PF13426 PAS_9
- InterPro
- cNMP-bd_dom, cNMP-bd_dom_sf, Ion_trans_dom, K_chnl_volt-dep_EAG/ELK/ERG, K_chnl_volt-dep_ERG, KCNH_animal-type, PAS, PAS-like_dom_sf, RmlC-like_jellyroll
- Functional cluster
- Protein Serine/Threonine Kinases
Experimental structures · PDB · 1
- 6Y7Q X-ray 1.39A
A predicted model is available from AlphaFold.
Gene Ontology · 7
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Voltage-gated inwardly rectifying potassium channel KCNH7 0.99
- Voltage-gated inwardly rectifying potassium channel KCNH7 0.99
- Voltage-gated inwardly rectifying potassium channel KCNH6 0.93
- Voltage-gated delayed rectifier potassium channel KCNH8 0.89
- Voltage-gated delayed rectifier potassium channel KCNH1 0.87
- Voltage-gated delayed rectifier potassium channel KCNH5 0.86
- Voltage-gated delayed rectifier potassium channel KCNH1 0.86
- Voltage-gated delayed rectifier potassium channel KCNH1 0.86
- Voltage-gated delayed rectifier potassium channel KCNH5 0.86
- Voltage-gated delayed rectifier potassium channel KCNH5 0.85
- Voltage-gated delayed rectifier potassium channel KCNH8 0.85
- Voltage-gated delayed rectifier potassium channel KCNH8 0.84
Co-cited proteins · studied together in the literature
- Voltage-gated inwardly rectifying potassium channel KCNH6 1 shared papers
Literature · 4 cited papers
- Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel. J. Biol. Chem. · 2020
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- HERG K(+) currents in human prolactin-secreting adenoma cells. Pflugers Arch. · 2003
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