Voltage-gated delayed rectifier potassium channel KCNH8
Also known as: KCNH8
Function
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents. Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium current at depolarizating voltages from -30 mV to +50mV. Shows no obvious change in the activation rate from different holding potentials. Activation is strongly dependent on the pH of the external solution (By similarity).
Classification
- Family (Pfam)
- PF00027 cNMP_binding, PF00520 Ion_trans, PF13426 PAS_9
- InterPro
- cNMP-bd_dom, cNMP-bd_dom_sf, Ion_trans_dom, K_chnl_volt-dep_EAG/ELK/ERG, K_chnl_volt-dep_ELK, KCNH_animal-type, PAC, PAS, PAS-assoc_C, PAS-like_dom_sf, RmlC-like_jellyroll
- Functional cluster
- Protein Serine/Threonine Kinases
Gene Ontology · 7
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Voltage-gated delayed rectifier potassium channel KCNH8 0.98
- Voltage-gated delayed rectifier potassium channel KCNH8 0.98
- Voltage-gated inwardly rectifying potassium channel KCNH6 0.90
- Voltage-gated inwardly rectifying potassium channel KCNH7 0.90
- Voltage-gated inwardly rectifying potassium channel KCNH7 0.89
- Voltage-gated inwardly rectifying potassium channel KCNH7 0.89
- Voltage-gated delayed rectifier potassium channel KCNH5 0.84
- Voltage-gated delayed rectifier potassium channel KCNH5 0.84
- Voltage-gated delayed rectifier potassium channel KCNH5 0.83
- Voltage-gated delayed rectifier potassium channel KCNH1 0.81
- Voltage-gated delayed rectifier potassium channel KCNH1 0.80
- Voltage-gated inwardly rectifying potassium channel KCNH6 0.80
Literature · 4 cited papers
- The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Distribution and functional properties of human KCNH8 (Elk1) potassium channels. Am. J. Physiol. · 2003
- A novel membrane potential-sensitive fluorescent dye improves cell-based assays for ion channels. J. Biomol. Screen. · 2002
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