Ephrin type-A receptor 6

Function

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).

Classification

Family (Pfam)

PF14575 EphA2_TM, PF25599 Ephrin_CRD, PF01404 Ephrin_lbd, PF07699 Ephrin_rec_like, PF00041 fn3, PF07714 PK_Tyr_Ser-Thr, PF00536 SAM_1

InterPro

EPH-A6_SAM, Eph_TM, EphA6_rcpt_lig-bd, Ephrin_rcpt_lig-bd_dom, Ephrin_rcpt_TKs, FN3_dom, FN3_sf, Galactose-bd-like_sf, Growth_fac_rcpt_cys_sf, Ig-like_fold, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, SAM, SAM/pointed_sf, Ser-Thr/Tyr_kinase_cat_dom, Tyr-kin_ephrin_A/B_rcpt-like, Tyr_kinase_AS, Tyr_kinase_cat_dom, Tyr_kinase_ephrin_rcpt, Tyr_kinase_rcpt_V_CS

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Gene Ontology · 6

• GO:0030425 dendrite
• GO:0005886 plasma membrane
• GO:0005524 ATP binding
• GO:0005005 transmembrane-ephrin receptor activity
• GO:0007411 axon guidance
• GO:0048013 ephrin receptor signaling pathway

Drugs targeting this protein · 1

• VANDETANIB inhibitor

Related proteins · sequence + function similarity

• Ephrin type-A receptor 6 1.00
• Ephrin type-A receptor 6 1.00
• Ephrin type-A receptor 3 0.94
• Ephrin type-B receptor 1 0.94
• Ephrin type-A receptor 3 0.94
• Ephrin type-B receptor 1 0.94
• Ephrin type-B receptor 1 0.94
• Ephrin type-A receptor 3 0.94
• Ephrin type-A receptor 3 0.94
• Ephrin type-A receptor 7 0.93
• Ephrin type-B receptor 1-A 0.93
• Ephrin type-A receptor 7 0.93

Literature · 4 cited papers

• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
• Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. Clin. Chem. · 2004