lmmol · Proteins

Protein deacetylase HDAC6

UniProt Q9UBN7 Organism Homo sapiens Gene HDAC6, KIAA0901 EC 3.5.1.-, 2.3.2.-

Also known as: HDAC6, KIAA0901

Function

Deacetylates a wide range of non-histone substrates. Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. Required for cilia disassembly via deacetylation of alpha-tubulin. Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Deacetylates SQSTM1. Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity. Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities. Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage. Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis. Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons. Deacetylates PRDM16 (By similarity). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region. In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage. Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Classification

Family (Pfam)
PF00850 Hist_deacetyl, PF02148 zf-UBP
InterPro
HDACs, His_deacetylse_dom, His_deacetylse_dom_sf, Ureohydrolase_dom_sf, Znf_RING/FYVE/PHD, Znf_UBP
Functional cluster
Eukaryotic Transcription Factors & related

Experimental structures · PDB · 21

A predicted model is available from AlphaFold.

Gene Ontology · 78

Disease associations

Drugs targeting this protein · 12

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 38 cited papers

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