Polyamine deacetylase HDAC10

Function

Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair.

Classification

Family (Pfam)

PF00850 Hist_deacetyl

InterPro

HDACs, His_deacetylse_dom, His_deacetylse_dom_sf, Ureohydrolase_dom_sf

Functional cluster

Eukaryotic Transcription Factors & related

Gene Ontology · 23

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0000118 histone deacetylase complex
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0047609 acetylputrescine deacetylase activity
• GO:0047611 acetylspermidine deacetylase activity
• GO:0019213 deacetylase activity
• GO:0019899 enzyme binding
• GO:0004407 histone deacetylase activity
• GO:0042826 histone deacetylase binding
• GO:0033558 protein lysine deacetylase activity
• GO:0008270 zinc ion binding
• GO:0006325 chromatin organization
• GO:0006281 DNA repair
• GO:0035825 homologous recombination
• GO:0016236 macroautophagy
• GO:0045892 negative regulation of DNA-templated transcription
• GO:0000122 negative regulation of transcription by RNA polymerase II
• GO:0106047 polyamine deacetylation
• GO:0032425 positive regulation of mismatch repair
• GO:0006355 regulation of DNA-templated transcription
• GO:0106048 spermidine deacetylation

Drugs targeting this protein · 10

• ABEXINOSTAT inhibitor
• QUISINOSTAT inhibitor
• TACEDINALINE inhibitor
• ENTINOSTAT inhibitor
• ROMIDEPSIN inhibitor
• PANOBINOSTAT LACTATE inhibitor
• FIMEPINOSTAT inhibitor
• BELINOSTAT inhibitor
• CUDC-101 inhibitor
• GIVINOSTAT HYDROCHLORIDE inhibitor

Related proteins · sequence + function similarity

• Polyamine deacetylase HDAC10 0.95
• Polyamine deacetylase HDAC10 0.94
• Nicotinate phosphoribosyltransferase 0.77
• Nicotinate phosphoribosyltransferase 0.76
• Nicotinate phosphoribosyltransferase 0.76
• GH3 domain-containing protein 0.75
• NADPH oxidase activator 1 0.75
• Hydroxyproline dehydrogenase 0.75
• Protein deacetylase HDAC6 0.74
• ATP-dependent DNA helicase Q4 0.74
• NADPH-dependent diflavin oxidoreductase 1 0.74
• Exonuclease mut-7 homolog 0.74

Co-cited proteins · studied together in the literature

• Polyamine deacetylase HDAC10 1 shared papers
• Polyamine deacetylase HDAC10 1 shared papers
• Histone deacetylase 3 1 shared papers
• Nuclear receptor corepressor 2 1 shared papers
• Histone deacetylase 2 1 shared papers

Literature · 15 cited papers

• Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance. Sci. Rep. · 2018
• Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. Nat. Commun. · 2017
• Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2. J. Biol. Chem. · 2015
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Histone deacetylase 10 promotes autophagy-mediated cell survival. Proc. Natl. Acad. Sci. U.S.A. · 2013
• Histone deacetylases 9 and 10 are required for homologous recombination. J. Biol. Chem. · 2011
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. · 2004
• An unappreciated role for RNA surveillance. Genome Biol. · 2004
• Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res. · 2002
• Isolation and characterization of a novel class II histone deacetylase, HDAC10. J. Biol. Chem. · 2002
• … and 3 more in the literature graph