Histone deacetylase 11
Also known as: HDAC11
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Classification
- Family (Pfam)
- PF00850 Hist_deacetyl
- InterPro
- HDAC_classIV, HDACs, His_deacetylse_dom, His_deacetylse_dom_sf, Ureohydrolase_dom_sf
- Functional cluster
- Ribosomal S8 & Metabolic Enzymes
Gene Ontology · 10
- GO:0000118 histone deacetylase complex
- GO:0005654 nucleoplasm
- GO:0005634 nucleus
- GO:0005886 plasma membrane
- GO:0140297 DNA-binding transcription factor binding
- GO:0004407 histone deacetylase activity
- GO:0141221 histone deacetylase activity, hydrolytic mechanism
- GO:0006325 chromatin organization
- GO:0006351 DNA-templated transcription
- GO:0040029 epigenetic regulation of gene expression
Drugs targeting this protein · 11
- ABEXINOSTAT inhibitor
- QUISINOSTAT inhibitor
- TACEDINALINE inhibitor
- MOCETINOSTAT inhibitor
- ENTINOSTAT inhibitor
- ROMIDEPSIN inhibitor
- PANOBINOSTAT LACTATE inhibitor
- FIMEPINOSTAT inhibitor
- BELINOSTAT inhibitor
- CUDC-101 inhibitor
- GIVINOSTAT HYDROCHLORIDE inhibitor
Related proteins · sequence + function similarity
- Histone deacetylase 11 1.00
- Histone deacetylase 11 0.98
- Histone deacetylase 2 0.82
- Histone deacetylase 8 0.71
- Histone deacetylase 8 0.70
- Histone deacetylase 8 0.69
- Histone deacetylase 8 0.67
- Histone deacetylase 8 0.67
- Histone deacetylase 8 0.67
- Histone deacetylase 8 0.66
- Histone deacetylase 7 0.64
- Histone deacetylase 9 0.62
Co-cited proteins · studied together in the literature
- Protein deacetylase HDAC6 1 shared papers
Literature · 5 cited papers
- The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
- The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J. Biol. Chem. · 2002
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