DNA polymerase epsilon subunit 3

Function

Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.

Classification

Family (Pfam)

PF00808 CBFD_NFYB_HMF

InterPro

CBFA_NFYB_domain, DNA_Pol-Epsilon_Subunit, Histone-fold

Functional cluster

Protein Serine/Threonine Kinases

Gene Ontology · 17

• GO:0140672 ATAC complex
• GO:0008623 CHRAC
• GO:0008622 epsilon DNA polymerase complex
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0031490 chromatin DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0046982 protein heterodimerization activity
• GO:0006338 chromatin remodeling
• GO:0006974 DNA damage response
• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0031507 heterochromatin formation
• GO:0006272 leading strand elongation
• GO:0000122 negative regulation of transcription by RNA polymerase II
• GO:0006334 nucleosome assembly
• GO:0006275 regulation of DNA replication

Drugs targeting this protein · 6

• FLUDARABINE PHOSPHATE inhibitor
• GEMCITABINE HYDROCHLORIDE inhibitor
• CLOFARABINE inhibitor
• TROXACITABINE inhibitor
• ASPACYTARABINE inhibitor
• CYTARABINE inhibitor

Related proteins · sequence + function similarity

• DNA polymerase epsilon subunit 3 1.00
• DNA polymerase epsilon subunit 3 1.00
• DNA polymerase epsilon subunit 3 0.99
• DNA polymerase epsilon subunit 3 0.83
• DNA polymerase epsilon subunit D 0.82
• DNA polymerase epsilon subunit D 0.79
• DNA polymerase epsilon subunit D 0.78
• DNA polymerase epsilon subunit D 0.78
• DNA polymerase epsilon subunit 3 0.77
• Transcriptional activator hap3 0.74
• DNA polymerase epsilon subunit D 0.74
• DNA polymerase epsilon subunit D 0.71

Co-cited proteins · studied together in the literature

• Chromatin accessibility complex protein 1 3 shared papers
• DNA polymerase epsilon subunit 4 1 shared papers
• Bromodomain adjacent to zinc finger domain protein 1A 3 shared papers
• SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 3 shared papers
• Bromodomain adjacent to zinc finger domain protein 1A 1 shared papers
• DNA polymerase epsilon subunit 2 1 shared papers
• DNA polymerase epsilon catalytic subunit A 1 shared papers

Literature · 12 cited papers

• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• DNA sequence and analysis of human chromosome 9. Nature · 2004
• The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. Mol. Cell · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Nat. Genet. · 2002
• HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. EMBO J. · 2000
• Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. J. Biol. Chem. · 2000