DNA polymerase epsilon subunit 2
Also known as: DPE2, POLE2
Function
Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity).
Classification
- Family (Pfam)
- PF04042 DNA_pol_E_B, PF12213 Dpoe2NT
- InterPro
- DNA_pol_a/d/e_bsu, DNA_pol_e_bsu_N, POLE2
- Functional cluster
- Mixed Regulatory & Membrane Proteins
Experimental structures · PDB · 4
A predicted model is available from AlphaFold.
Gene Ontology · 9
Drugs targeting this protein · 6
- FLUDARABINE PHOSPHATE inhibitor
- GEMCITABINE HYDROCHLORIDE inhibitor
- CLOFARABINE inhibitor
- TROXACITABINE inhibitor
- ASPACYTARABINE inhibitor
- CYTARABINE inhibitor
Related proteins · sequence + function similarity
- DNA polymerase epsilon subunit 2 0.99
- DNA polymerase epsilon subunit 2 0.99
- DNA polymerase epsilon subunit 2 0.99
- Origin recognition complex subunit 5 0.68
- Origin recognition complex subunit 5 0.67
- Regulator of MON1-CCZ1 complex 0.67
- Regulator of MON1-CCZ1 complex 0.67
- VPS35 endosomal protein-sorting factor-like 0.66
- VPS35 endosomal protein-sorting factor-like 0.66
- Protein transport protein Sec23A 0.65
- BBSome complex member BBS7 0.65
- Protein transport protein Sec23A 0.65
Co-cited proteins · studied together in the literature
- DNA polymerase epsilon subunit 2 1 shared papers
- DNA polymerase epsilon subunit 4 1 shared papers
- DNA polymerase epsilon subunit 3 1 shared papers
- DNA polymerase epsilon catalytic subunit A 3 shared papers
- WD repeat and HMG-box DNA-binding protein 1 2 shared papers
- Cell division control protein 45 homolog 2 shared papers
- DNA replication complex GINS protein PSF2 2 shared papers
- DNA replication licensing factor MCM5 2 shared papers
- TIMELESS-interacting protein 2 shared papers
- DNA replication licensing factor MCM4 2 shared papers
- DNA replication complex GINS protein PSF1 2 shared papers
- DNA replication complex GINS protein PSF3 2 shared papers
Literature · 9 cited papers
- A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature · 2021
- Structure of a human replisome shows the organisation and interactions of a DNA replication machine. EMBO J. · 2021
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- The DNA sequence and analysis of human chromosome 14. Nature · 2003
- E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase varepsilon B-subunit gene POLE2. Nucleic Acids Res. · 2001
- Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. J. Biol. Chem. · 2000
- The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon. Nucleic Acids Res. · 1998
- Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. J. Biol. Chem. · 1997
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