Leukotriene B4 receptor 2
Also known as: BLT2R, BLTR2, LTB4R2
Function
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Leukotriene_B4_rcpt, Leukotriene_B4_typ-2_rcpt
- Functional cluster
- G Protein-Coupled Receptors
Gene Ontology · 8
- GO:0016020 membrane
- GO:0005886 plasma membrane
- GO:0008528 G protein-coupled peptide receptor activity
- GO:0001632 leukotriene B4 receptor activity
- GO:0004974 leukotriene receptor activity
- GO:0006935 chemotaxis
- GO:0007194 negative regulation of adenylate cyclase activity
- GO:0007218 neuropeptide signaling pathway
Drugs targeting this protein · 1
- CP-195543 antagonist
Related proteins · sequence + function similarity
- Leukotriene B4 receptor 2 1.00
- Leukotriene B4 receptor 2 1.00
- C-C chemokine receptor type 10 0.95
- C-C chemokine receptor type 10 0.94
- Leukotriene B4 receptor 1 0.94
- C-X-C chemokine receptor GPR25 0.94
- C-X-C chemokine receptor GPR25 0.93
- Free fatty acid receptor 1 0.92
- Free fatty acid receptor 1 0.92
- Leukotriene B4 receptor 1 0.91
- G protein-coupled receptor 4 0.91
- Proteinase-activated receptor 4 0.91
Co-cited proteins · studied together in the literature
- Leukotriene B4 receptor 2 1 shared papers
- Leukotriene B4 receptor 2 1 shared papers
- Putative vomeronasal receptor-like protein 4 1 shared papers
- Probable G protein-coupled receptor 160 1 shared papers
- Probable G protein-coupled receptor 152 1 shared papers
- Cysteinyl leukotriene receptor 2 1 shared papers
- Probable G protein-coupled receptor 148 1 shared papers
- Putative G protein-coupled receptor GPR32P1 1 shared papers
- Probable G protein-coupled receptor 174 1 shared papers
- Oxoeicosanoid receptor 1 1 shared papers
- GPI ethanolamine phosphate transferase 3, catalytic subunit 1 shared papers
- Transmembrane protein 171 1 shared papers
Literature · 6 cited papers
- The DNA sequence and analysis of human chromosome 14. Nature · 2003
- Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett. · 2002
- A novel hepatointestinal leukotriene B4 receptor: cloning and functional characterization. J. Biol. Chem. · 2000
- A second leukotriene B4 receptor, BLT2: a new therapeutic target in inflammation and immunological disorders. J. Exp. Med. · 2000
- Cloning and characterization of cDNA encoding a novel human leukotriene B4 receptor. Biochem. Biophys. Res. Commun. · 2000
- Molecular cloning and characterization of another leukotriene B4 receptor. J. Biol. Chem. · 2000
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