Proteinase-activated receptor 4
Also known as: F2RL3, PAR4
Function
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Prot_act_rcpt_4, Protea_act_rcpt
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 2
A predicted model is available from AlphaFold.
Gene Ontology · 13
- GO:0005576 extracellular region
- GO:0005886 plasma membrane
- GO:0004930 G protein-coupled receptor activity
- GO:0002020 protease binding
- GO:0015057 thrombin-activated receptor activity
- GO:0007596 blood coagulation
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:0030168 platelet activation
- GO:0060155 platelet dense granule organization
- GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
- GO:0009611 response to wounding
- GO:0007165 signal transduction
Drugs targeting this protein · 1
- BMS-986141 antagonist
Related proteins · sequence + function similarity
- Proteinase-activated receptor 4 0.99
- Proteinase-activated receptor 4 0.98
- C-C chemokine receptor type 10 0.94
- C-C chemokine receptor type 10 0.93
- Free fatty acid receptor 1 0.92
- Free fatty acid receptor 1 0.92
- P2Y purinoceptor 11 0.92
- Lysophosphatidic acid receptor 5 0.91
- Leukotriene B4 receptor 2 0.91
- Leukotriene B4 receptor 2 0.91
- Leukotriene B4 receptor 2 0.91
- C-X-C chemokine receptor GPR25 0.90
Co-cited proteins · studied together in the literature
- Proteinase-activated receptor 4 2 shared papers
- Cysteine proteinase mucunain 1 shared papers
- Proteinase-activated receptor 3 1 shared papers
- Proteinase-activated receptor 1 1 shared papers
- Proteinase-activated receptor 2 1 shared papers
Literature · 6 cited papers
- Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors. J. Neurosci. · 2008
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J. Clin. Invest. · 1999
- Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. J. Biol. Chem. · 1998
- A dual thrombin receptor system for platelet activation. Nature · 1998
- Cloning and characterization of human protease-activated receptor 4. Proc. Natl. Acad. Sci. U.S.A. · 1998
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.