Leukotriene B4 receptor 1

Function

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

Formyl_rcpt-rel, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Leukotriene_B4_rcpt, Leukotriene_B4_typ-1_rcpt

Functional cluster

G Protein-Coupled Receptors

Experimental structures · PDB · 2

• 7K15 X-ray 2.88A
• 7VKT EM 2.90A

A predicted model is available from AlphaFold.

Gene Ontology · 11

• GO:0005886 plasma membrane
• GO:0008528 G protein-coupled peptide receptor activity
• GO:0001632 leukotriene B4 receptor activity
• GO:0004974 leukotriene receptor activity
• GO:0000166 nucleotide binding
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0006955 immune response
• GO:0006954 inflammatory response
• GO:0006936 muscle contraction
• GO:0007218 neuropeptide signaling pathway
• GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway

Drugs targeting this protein · 3

• AMELUBANT antagonist
• CP-195543 antagonist
• ETALOCIB antagonist

Related proteins · sequence + function similarity

• Leukotriene B4 receptor 1 0.99
• Leukotriene B4 receptor 1 0.98
• Leukotriene B4 receptor 1 0.98
• Leukotriene B4 receptor 2 0.94
• Leukotriene B4 receptor 2 0.94
• Leukotriene B4 receptor 2 0.94
• B1 bradykinin receptor 0.92
• C-X-C chemokine receptor type 3 0.92
• B1 bradykinin receptor 0.92
• C-C chemokine receptor type 10 0.92
• B1 bradykinin receptor 0.92
• C-X-C chemokine receptor type 3 0.92

Co-cited proteins · studied together in the literature

• Uracil nucleotide/cysteinyl leukotriene receptor 1 shared papers

Literature · 7 cited papers

• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization. J. Biol. Chem. · 2002
• Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. J. Exp. Med. · 2000
• A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature · 1997
• Cloning of cDNA encoding a putative chemoattractant receptor. Genomics · 1996
• Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells. J. Biol. Chem. · 1996
• New members of the chemokine receptor gene family. J. Leukoc. Biol. · 1996