DNA helicase/primase complex-associated protein
Function
Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
Classification
- Family (Pfam)
- PF03324 Herpes_HEPA
- InterPro
- HSV_HEPA
- Functional cluster
- Viral Structural & Replication Proteins
Gene Ontology · 3
Drugs targeting this protein · 1
- AMENAMEVIR inhibitor
Related proteins · sequence + function similarity
- DNA helicase/primase complex-associated protein 1.00
- DNA helicase/primase complex-associated protein 0.80
- DNA replication helicase 0.64
- DNA helicase/primase complex-associated protein 0.62
- DNA helicase/primase complex-associated protein 0.62
- Protein ORF10 0.62
- Microtubule-associated protein VP5 0.62
- Uncharacterized gene 72 protein 0.62
- Capsid vertex component 1 0.60
- DNA primase 0.60
- DNA primase 0.60
- Protein U54 0.60
Co-cited proteins · studied together in the literature
- Cytoplasmic envelopment protein 3 1 shared papers
- Uracil-DNA glycosylase 1 shared papers
- DNA replication helicase 1 shared papers
- Transcriptional regulator ICP22 homolog 1 shared papers
- Replication origin-binding protein 1 shared papers
- Nuclear protein UL4 homolog 1 shared papers
- Nuclear phosphoprotein UL3 homolog 1 shared papers
- Uncharacterized protein 57 1 shared papers
- Envelope glycoprotein L 1 shared papers
- Envelope glycoprotein M 1 shared papers
- Envelope protein US9 1 shared papers
- Major viral transcription factor ICP4 homolog 1 shared papers
Literature · 2 cited papers
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