DNA primase
Function
Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
Classification
- Family (Pfam)
- PF03121 Herpes_UL52
- InterPro
- HSV_PRIM
- Functional cluster
- S-Adenosylmethionine Synthases & related
Gene Ontology · 5
Drugs targeting this protein · 1
- AMENAMEVIR inhibitor
Related proteins · sequence + function similarity
- DNA primase 1.00
- DNA primase 0.85
- DNA primase 0.83
- DNA primase 0.83
- DNA primase 0.79
- DNA primase 0.79
- DNA primase 0.77
- DNA primase 0.76
- DNA primase 0.75
- DNA primase 0.73
- DNA primase 0.72
- DNA primase 0.72
Literature · 2 cited papers
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